Background: Early-onset dementia (EOD) defines all dementia related conditions with an onset before the age of 65 years. EOD places a large and distressing psychological, emotional and financial burden on the individuals themselves and their caregivers. For various reasons, diagnostic and treatment strategies for EOD are very challenging. There is a general agreement that not only the human body but also the mind benefits from physical activity and/or exercise. Especially aerobic exercise has shown to have favorable effects on cognitive functions in healthy older adults, as well as in patients with MCI and dementia. However, there are major differences in age, physical fitness level and clinical presentation between EOD and late-onset dementia. Therefore, one cannot just assume that the same type and intensity of exercise will lead to similar effects in the former population. By conducting this scoping review, the authors aimed to identify the evidence on the effectiveness of aerobic exercise on physical and mental health outcomes in individuals with EOD, display gaps in this context, and formulate related directions for future research. Summary: There are a number of reasons to assume that aerobic exercise might be extremely valuable within individuals with EOD. However, this scoping review led to the surprising and striking finding that not a single study so far has investigated the effects of physical exercise on cognition, physical performance and feelings of well-being and quality of life in EOD. Although nowadays the disease is increasingly recognized, coping and (non-pharmacological) treatment strategies for EOD are virtually non-existent. Key Messages: Exercise intervention studies in EOD are lacking. With this scoping review the authors hope to inspire researchers in the field for related directions for future research. The potential beneficial effects of aerobic exercise in individuals with EOD should be explored and assessed extensively. Secondarily, decent guidelines for non-pharmacological treatment and coping strategies should be developed, with the aim of supporting people with EOD and their caregivers.
Dement Geriatr Cogn Disord

中文翻译：

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有氧运动对早发性痴呆患者的影响：范围综述

背景：早发性痴呆 (EOD) 定义了所有在 65 岁之前发病的痴呆相关病症。EOD 给个人及其照顾者带来了巨大而令人痛苦的心理、情感和经济负担。由于各种原因，EOD 的诊断和治疗策略非常具有挑战性。人们普遍认为，身体活动和/或锻炼不仅有益于人体，也有益于心灵。尤其是有氧运动已证明对健康老年人以及患有 MCI 和痴呆症的患者的认知功能产生有利影响。然而，EOD 和迟发性痴呆在年龄、身体健康水平和临床表现方面存在重大差异。所以，不能仅仅假设相同类型和强度的运动会对前一人群产生类似的影响。通过进行此范围界定审查，作者旨在确定有氧运动对 EOD 个体身心健康结果的有效性的证据，显示这方面的差距，并为未来的研究制定相关方向。总结：有很多理由认为有氧运动对 EOD 患者可能非常有价值。然而，这项范围界定审查导致了一个令人惊讶和惊人的发现，迄今为止，没有一项研究调查过体育锻炼对 EOD 中的认知、身体表现、幸福感和生活质量的影响。尽管如今人们越来越多地认识到这种疾病，但几乎不存在针对 EOD 的应对和（非药物）治疗策略。关键信息：缺乏 EOD 中的运动干预研究。通过本次范围界定审查，作者希望启发该领域的研究人员为未来的研究寻找相关方向。应广泛探索和评估有氧运动对 EOD 患者的潜在有益影响。其次，应制定非药物治疗和应对策略的体面指南，以支持 EOD 患者及其照顾者。
老年痴呆症认知障碍