Abstract

Patients with coronavirus disease 2019 (COVID-19) from novel coronavirus (SARS-CoV-2) infection may present with immune thrombocytopenia (ITP). Multisystem inflammatory syndrome in children (MIS-C) is a serious complication of SARS-CoV-2 causing systemic organ dysfunction. This case series presents the first reported cases of patients who developed ITP following MIS-C, while completing corticosteroid tapers. These patients responded to standard of care therapies for ITP and had appropriate platelet count recovery. We emphasize the importance of careful monitoring of those recovering from COVID-19 or MIS-C, to proactively identify clinical and laboratory abnormalities, in addition to long-term cardiovascular sequelae.

摘要

来自新型冠状病毒 (SARS-CoV-2) 感染的 2019 年冠状病毒病 (COVID-19) 患者可能会出现免疫性血小板减少症 (ITP)。儿童多系统炎症综合征 (MIS-C) 是 SARS-CoV-2 导致全身器官功能障碍的严重并发症。本病例系列介绍了首次报道的在 MIS-C 后发生 ITP 并完成皮质类固醇减量的患者病例。这些患者对 ITP 的标准护理疗法有反应，并有适当的血小板计数恢复。我们强调仔细监测 COVID-19 或 MIS-C 康复者的重要性，以主动识别临床和实验室异常以及长期心血管后遗症。