The quality of one’s romantic relationship is associated with mental health. Low levels of relationship quality may be a stressor that triggers a predisposition or diathesis to mental illness. Analyses were conducted to examine whether relationship quality moderated the association between polygenic risk scores (PRSs) for several mental health syndromes on phenotypic measures of those syndromes. Data were drawn from the Midlife in the United States (MIDUS) study of health and well-being. A subsample was genotyped, and PRSs were calculated. The PRS for anxiety was more strongly related to the anxiety phenotype when satisfaction was low than when satisfaction was high, providing evidence of a genetic susceptibility process between marital distress and anxiety. The expression of genetic influences on a phenotype in the presence of certain environmental stressors is complex and may depend on the specific phenotype and the methodology by which genetic influences are estimated.

浪漫关系的质量与心理健康有关。低水平的关系质量可能是引发精神疾病倾向或素质的压力源。进行分析以检查关系质量是否调节了几种心理健康综合征的多基因风险评分（PRS）与这些综合征的表型测量之间的关联。数据来自美国中年 (MIDUS) 健康和福祉研究。对子样本进行基因分型，并计算 PRS。当满意度低时，焦虑的 PRS 与焦虑表型的相关性比满意度高时的相关性更强，这为婚姻困扰和焦虑之间的遗传易感性过程提供了证据。在存在某些环境应激源的情况下，遗传对表型的影响的表达是复杂的，并且可能取决于特定的表型和估计遗传影响的方法。