Cryptosporidiosis is an intestinal protozoal disease of public health importance caused by Cryptosporidium spp. Despite the high synanthropism of raccoons, studies describing the pathology of Cryptosporidium spp. infections in this species are lacking. Therefore, we characterized the pathology of cryptosporidiosis in 2 juvenile raccoons. In addition, we conducted a retrospective search of the database of the California Animal Health and Food Safety laboratory for 1990–2019 and found 6 additional cases of cryptosporidiosis in raccoons. Sequencing of cryptosporidia was performed in one autopsied raccoon, and PCR on formalin-fixed, paraffin-embedded tissues in archived cases. The Cryptosporidium skunk genotype (CSkG), a strain of zoonotic relevance, was detected in 6 of 8 cases (75%). Frequently, cryptosporidiosis was associated with enteritis, eosinophilic infiltrates, villus atrophy or blunting and/or fusion, and crypt abscesses or necrosis. In 7 of the 8 cases, there was confirmed concurrent coinfection with canine distemper virus; 1 case was coinfected with canine parvovirus. Although crypt necrosis is considered a classic lesion of canine parvoviral infection in mesocarnivores and not a hallmark of cryptosporidiosis, results suggest that canine distemper virus is capable of mimicking such lesions in combination with cryptosporidia and immunosuppression.

隐孢子虫病是一种由隐孢子虫引起的具有公共卫生重要性的肠道原生动物疾病。尽管浣熊具有高度的共生性，但研究描述了隐孢子虫属的病理学。缺乏该物种的感染。因此，我们描述了 2 只幼年浣熊隐孢子虫病的病理学特征。此外，我们对加州动物健康和食品安全实验室 1990-2019 年的数据库进行了回顾性搜索，发现浣熊还有 6 例隐孢子虫病。对一只尸检浣熊进行了隐孢子虫测序，并在存档病例中对福尔马林固定、石蜡包埋的组织进行了 PCR。隐孢子虫臭鼬基因型 (CSkG) 是一种与人畜共患病相关的菌株，在 8 例中的 6 例 (75%) 中检测到。通常，隐孢子虫病与肠炎、嗜酸性粒细胞浸润、绒毛萎缩或钝化和/或融合，以及隐窝脓肿或坏死有关。8例中有7例确认并发感染犬瘟热病毒；1例合并感染犬细小病毒。尽管隐窝坏死被认为是中肉食动物犬细小病毒感染的典型病变，而不是隐孢子虫病的标志，但结果表明犬瘟热病毒能够结合隐孢子虫和免疫抑制来模拟此类病变。