In several parts of the world, Boswellia sacra Fluck. is one of the most commonly used herbs for the treatment of arthritis. Its usage should be validated in light of recent findings of haematotoxicity. This study was aimed to determine the effect of chronic administration of standardized methanolic extract of frankincense on blood cell count in experimental animals. Using high-performance liquid chromatography, the active constituents of B. sacra extract; boswellic acids were analyzed. The effect of three different doses of the extract (250, 500, and 1000 mg/kg) on different blood cells and associated parameters was investigated. The behavior, food, and water consumption of the rats were recorded. Boswellic acids were present in varying amounts with α-boswellic acid and β-boswellic acid present in more amounts compared to other boswellic acids in the extract. All three doses tested had no effect on the animals’ behavior, food consumption, or weight gain. The administration of a low (500 mg/kg) and high (1000 mg/kg) dose of the extract resulted in a non-dose dependent reduction in MCH (p < 0.01 and p < 0.05, respectively), but no other blood parameters were significantly affected. The B. sacra extract produces hypochromic normocytic anemia in rats at higher doses of 500 and 1000 mg/kg and this effect was not dose-dependent.

在世界多个地区，Boswellia sacra Fluck。是治疗关节炎最常用的草药之一。其使用应根据最近的血液毒性发现进行验证。本研究旨在确定长期服用标准化乳香甲醇提取物对实验动物血细胞计数的影响。采用高效液相色谱法，对B. sacra提取物的活性成分进行分析；分析了乳香酸。研究了三种不同剂量的提取物（250、500 和 1000 mg/kg）对不同血细胞和相关参数的影响。记录大鼠的行为、食物和水的消耗。乳香酸以不同的量存在，其中与提取物中的其他乳香酸相比，α-乳香酸和β-乳香酸的存在量更多。测试的所有三种剂量对动物的行为、食物消耗或体重增加没有影响。施用低剂量（500 mg/kg）和高剂量（1000 mg/kg）提取物会导致 MCH 非剂量依赖性降低（分别为p  < 0.01 和p  < 0.05），但没有其他血液参数受到显着影响。B. sacra提取物在 500 和 1000 mg/kg 的较高剂量下会在大鼠中产生低色素正细胞性贫血，并且这种作用不依赖于剂量。