Background and purpose

Flow diversion of aneurysms located in the M1 segment and middle cerebral artery bifurcation with Pipeline embolization device is sometimes performed, but further study is needed to support its regular use in aneurysm treatment. Here, we report measures of safety and efficacy for Pipeline embolization in the proximal middle cerebral artery in a multi-center cohort.

Materials and methods

Clinical and angiographic data of eligible patients were retrospectively obtained from participating centers and assessed for key clinical and angiographic outcomes. Additional details were extracted for patients with complications.

Results

In our multi-center cohort, complete aneurysm occlusion was achieved in 71% (17/24) of treated aneurysms. There were no deaths or disabling strokes, but non-disabling ischemic strokes occurred in 8% (2/24) of patients. For aneurysms in the M1 segment, complete aneurysm occlusion was observed in 75% (12/16) of aneurysms, aneurysm volume reduction was observed in 100% (16/16) of aneurysms, and non-disabling ischemic strokes occurred in 13% (2/16) of patients. For aneurysms at the middle cerebral artery bifurcation, complete aneurysm occlusion was observed in 63% (5/8) of aneurysms, aneurysm volume reduction occurred in 88% (7/8) of aneurysms, and ischemic or hemorrhagic complications occurred in 0% (0/8) of patients.

Conclusion

Pipeline embolization of cerebral aneurysms in the M1 segment and middle cerebral artery bifurcation demonstrated a 71% rate of complete aneurysm occlusion. There were no deaths or disabling strokes, but there was an 8% rate of non-disabling ischemic strokes.

中文翻译：

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近端大脑中动脉动脉瘤的管道栓塞：一项多中心队列研究

背景和目的

有时使用 Pipeline 栓塞装置对位于 M1 段和大脑中动脉分叉处的动脉瘤进行分流，但需要进一步研究以支持其在动脉瘤治疗中的常规使用。在这里，我们报告了多中心队列中大脑中动脉近端管道栓塞的安全性和有效性测量。

材料和方法

从参与中心回顾性获得符合条件的患者的临床和血管造影数据，并评估关键临床和血管造影结果。为有并发症的患者提取了额外的细节。

结果

在我们的多中心队列中，71% (17/24) 的已治疗动脉瘤实现了完全动脉瘤闭塞。没有死亡或致残性中风，但 8% (2/24) 的患者发生非致残性缺血性中风。对于 M1 段的动脉瘤，75% (12/16) 的动脉瘤观察到动脉瘤完全闭塞，100% (16/16) 的动脉瘤观察到动脉瘤体积缩小，13% 发生非致残性缺血性卒中。 2/16) 的患者。对于大脑中动脉分叉处的动脉瘤，63%（5/8）的动脉瘤完全闭塞，88%（7/8）的动脉瘤出现动脉瘤体积缩小，0%的动脉瘤出现缺血性或出血性并发症。 0/8) 的患者。

结论

M1 段和大脑中动脉分叉处脑动脉瘤的管道栓塞表明完全动脉瘤闭塞率为 71%。没有死亡或致残性中风，但非致残性缺血性中风的发生率为 8%。