Antioxidants and related compounds are anti-inflammatory and exhibit great potential in promoting human health. They are also often considered to be important elements in the process of neurodegeneration. Here we describe a antioxidant blend of Curcumin and Broccoli Seed Extract (BSE). Flies treated with the blend exhibit extended lifespan. RNA-seq analysis of samples from adult fly brains reveals a wide array of new genes with differential expression upon treatment with the blend. Interestingly, abolishing expression of some of the identified genes in dopaminergic (DA) neurons does not affect DA neuron number. Taken together, our findings reveal an antioxidant blend that promotes fly longevity and exhibits protective effect over neurodegeneration, demonstrating the importance of antioxidants in health and pathology.

抗氧化剂和相关化合物具有抗炎作用，在促进人类健康方面表现出巨大的潜力。它们也经常被认为是神经变性过程中的重要因素。在这里，我们描述了姜黄素和西兰花籽提取物 (BSE) 的抗氧化剂混合物。用该混合物处理的苍蝇表现出更长的寿命。对成年果蝇大脑样本的 RNA 序列分析揭示了一系列在混合物处理后具有差异表达的新基因。有趣的是，消除多巴胺能 (DA) 神经元中一些已识别基因的表达不会影响 DA 神经元的数量。总而言之，我们的研究结果揭示了一种抗氧化剂混合物可以促进果蝇寿命并对神经退行性疾病表现出保护作用，这证明了抗氧化剂在健康和病理学中的重要性。