Background: Cell death is a fundamental biological phenomenon that contributes to the pathogenesis of various diseases. Regulation of iron and iron metabolism has received considerable research interests especially concerning the progression of metabolic diseases.

Discussion: Emerging evidence shows that ferroptosis, a non-apoptotic programmed cell death induced by iron-dependent lipid peroxidation, contributes to the development of complex diseases such as non-alcoholic steatohepatitis, cardiomyopathy, renal ischemia-reperfusion, and neurodegenerative diseases. Therefore, inhibiting ferroptosis can improve the pathophysiology of associated metabolic diseases. This review describes the vital role of ferroptosis in mediating the development of certain metabolic diseases. Besides, the potential risk of iron and ferroptosis in atherosclerosis and cardiovascular diseases is also described. Iron overload and ferroptosis are potential secondary causes of death in metabolic diseases. Moreover, this review also provides potential novel approaches against ferroptosis based on recent research advances.

Conclusion: Several controversies exist concerning mechanisms underlying ferroptotic cell death in metabolic diseases, particularly in atherosclerosis. Since ferroptosis participates in the progression of metabolic diseases such as non-alcoholic steatohepatitis (NASH), there is a need to develop new drugs targeting ferroptosis to alleviate such diseases.

背景：细胞死亡是一种基本的生物学现象，可导致多种疾病的发病。铁和铁代谢的调节已引起相当大的研究兴趣，特别是关于代谢疾病的进展。

讨论：新兴证据表明，铁依赖性脂质过氧化引起的非凋亡性程序性细胞死亡是铁变性，导致非酒精性脂肪性肝炎，心肌病，肾缺血-再灌注和神经退行性疾病等复杂疾病的发展。因此，抑制铁锈病可以改善相关代谢疾病的病理生理。这篇综述描述了铁锈病在介导某些代谢性疾病发展中的重要作用。此外，还描述了在动脉粥样硬化和心血管疾病中铁和铁的潜在风险。铁超负荷和肥大症是代谢疾病中潜在的继发性死亡原因。此外，本综述还基于最近的研究进展提供了潜在的新颖方法，可用于防治铁锈病。

结论：关于代谢性疾病，尤其是动脉粥样硬化中促铁细胞死亡的机制存在一些争议。由于ferroptosis参与了诸如非酒精性脂肪性肝炎（NASH）之类的代谢性疾病的发展，因此需要开发针对fertroposis的新药以减轻此类疾病。