Background: Reducing the healing time of wounds can decrease the patient's immobility time and their medical costs, leading a faster return of the patients to daily work.

Objective: The aim of the present study is to compare the effect of adipose-derived stem cells and curcumin- containing liposomal nanoparticles with phenytoin on wound healing.

Methods: After anesthesia of the rats, open skin ulcers were made by a bistoury blade. Subsequently, stem cells were removed from the adipose tissue of the upper border of the epididymis. The originality of stem cells was then confirmed by the flow cytometry. The fusion method was used to prepare the liposome; and also, nanoliposomal particles were confirmed by using the DLS microscope. The percentage of recovery and the cell count was measured with IMAGEJ. The expression of genes was assessed by PCR. The number of fibroblasts was counted by immunohistochemistry techniques. The amount of collagen was determined by Tri-chromosome staining, and the number of capillaries was enumerated by H & E staining.

Results: The expression of the TGF-β1 gene, vascular number, wound healing rate and the number of fibroblasts increased significantly in adipose tissue-derived stem cells and curcumin nanoliposome groups (p<0.05); the wound surface was also decreased significantly (p<0.05).

Conclusion: Based on the results of our research, adipose tissue-derived stem cells and curcumin nanoliposomes can heal wounds efficiently.

背景：减少伤口的愈合时间可以减少患者的不动时间和医疗费用，从而使患者更快地回到日常工作中。

目的：本研究的目的是比较脂肪干细胞和含苯妥英的含姜黄素的脂质体纳米颗粒对伤口愈合的作用。

方法：大鼠麻醉后，用双刃刀制造开放性皮肤溃疡。随后，从附睾上边界的脂肪组织中去除干细胞。然后通过流式细胞术确认干细胞的独创性。用融合法制备脂质体。并且，通过DLS显微镜确认了纳米脂质体颗粒。使用IMAGEJ测量回收率和细胞计数。通过PCR评估基因的表达。通过免疫组织化学技术计数成纤维细胞的数量。通过三染色体染色确定胶原蛋白的量，并且通过H＆E染色计数毛细血管的数目。

结果：脂肪组织来源的干细胞和姜黄素纳米脂质体组中TGF-β1基因的表达，血管数目，伤口愈合率和成纤维细胞数目显着增加（p <0.05）；伤口表面也明显减少（p <0.05）。

结论：根据我们的研究结果，脂肪组织干细胞和姜黄素纳米脂质体可以有效地治愈伤口。