Aim: This study aimed to investigate the effect of Micromeria graeca on blood glucose levels and lipid parameters in an experimental model of diabetes.

Background: Micromeria graeca (L.) Benth. ex Rchb is a medicinal plant used in Morocco for the treatment of several pathologies including diabetes.

Objective: This study aimed to evaluate the antihyperglycemic and antihyperlipidemic effects of the aqueous extract of Micromeria graeca (M. graeca) aerial parts (AEMG) under physiological (normal rats) and pathological (STZ-induced diabetic rats) conditions. Additionally, we analyzed the phytochemical composition and antioxidant capacity.

Methods: The effects of the acute and sub-chronic administration of AEMG (20 mg/kg) on blood glucose levels and lipid profiles were evaluated in normal and streptozotocin-induced diabetic rats. Moreover, the phytochemical analysis was carried with standard tests and estimation of total phenolics compounds by Folin–Ciocalteu reagent. The antioxidant activity was realized by the DPPH method.

Results: Single oral administration of M. graeca aqueous extract decreased blood glucose levels 4 and 6 hours (p<0.01) after treatment in diabetic rats. In accordance, the repeated oral administration of M. graeca showed a significant reduction in blood glucose levels in diabetic rats since the second day to the end of the period experiment (p<0.0001). In addition, two weeks of treatment with M. graeca reduced total cholesterol levels (p<0.05) with a significant increase of HDL-c level (p<0.01) in diabetic rats. Moreover, M. graeca scavenged DPPH radical in a dose-dependent manner (IC50=0.48 mg/ml), whereas IC50 was 0.55 mg/ml for BHT. Phytochemical analysis showed the richness of Micromeria graeca on polyphenols (281.94±4.61 mg GAE/1 g), flavonoids, tannins, glycosides, saponins, sterols, sesquiterpenes, and terpenoids.

Conclusion: AEMG exhibits antihyperglycemic and antihyperlipidemic activities in STZ-induced diabetic rats and a potent antioxidant capacity.

目的：本研究旨在研究Micromeria graeca对糖尿病实验模型中血糖水平和脂质参数的影响。

背景：Micromeria graeca（L.）Benth。ex Rchb是摩洛哥的药用植物，可用于治疗多种疾病，包括糖尿病。

目的：本研究旨在评估在生理（正常大鼠）和病理（STZ诱导的糖尿病大鼠）条件下的草Micro微小部位（AEMG）水提物（AEMG）的降血糖和降血脂作用。此外，我们分析了植物化学成分和抗氧化能力。

方法：在正常和链脲佐菌素诱导的糖尿病大鼠中，评估了AEMG（20 mg / kg）的急性和亚慢性给药对血糖水平和血脂谱的影响。此外，通过标准测试进行植物化学分析，并通过Folin–Ciocalteu试剂估算总酚类化合物。抗氧化剂活性通过DPPH方法实现。

结果：在糖尿病大鼠中，单次口服graeca水提取物可降低治疗后4和6小时的血糖水平（p <0.01）。因此，从第二天到周期试验结束，重复口服给予的格拉斯莫卡氏菌显示糖尿病大鼠血糖水平显着降低（p <0.0001）。另外，在糖尿病大鼠中，用graeca进行的治疗两周降低了总胆固醇水平（p <0.05），而HDL-c水平显着升高（p <0.01）。此外，M。graeca以剂量依赖性方式清除了DPPH自由基（IC50 = 0.48 mg / ml），而BHT的IC50为0.55 mg / ml。植物化学分析显示，草m富含多酚（281.94±4.61 mg GAE / 1 g），类黄酮，单宁，糖苷，皂角苷，固醇，倍半萜和萜烯类化合物。

结论：AEMG在STZ诱导的糖尿病大鼠中具有降血糖和降血脂活性，并且具有强大的抗氧化能力。