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Autoantibodies Among HIV-1 Infected Individuals and the Effect of Anti-Retroviral Therapy (ART) on It
Current HIV Research ( IF 0.8 ) Pub Date : 2021-05-01 , DOI: 10.2174/1570162x19666210217120337 Runal John Steve 1 , Diviya Alex 1 , Binesh Lal Yesudhason 2 , John Antony Jude Prakash 2 , Nitty Skariah Mathews 3 , Dolly Daniel 3 , Veena Vadhini Ramalingam 1 , John Paul Demosthenes 1 , Ben Chirag Ghale 1 , Raghavendran Anantharam 1 , Grace Rebekah 4 , Priscilla Rupali 5 , George Mannil Varghese 5 , Rajesh Kannangai 1
中文翻译：
HIV-1 感染者的自身抗体和抗逆转录病毒疗法 (ART) 对其的影响
更新日期：2021-05-06
Current HIV Research ( IF 0.8 ) Pub Date : 2021-05-01 , DOI: 10.2174/1570162x19666210217120337 Runal John Steve 1 , Diviya Alex 1 , Binesh Lal Yesudhason 2 , John Antony Jude Prakash 2 , Nitty Skariah Mathews 3 , Dolly Daniel 3 , Veena Vadhini Ramalingam 1 , John Paul Demosthenes 1 , Ben Chirag Ghale 1 , Raghavendran Anantharam 1 , Grace Rebekah 4 , Priscilla Rupali 5 , George Mannil Varghese 5 , Rajesh Kannangai 1
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Background: Antiretroviral therapy (ART) has led to a decline in autoimmune diseases but lacks studies on its effect on autoantibodies.
Methods: It is a cross-sectional study with archived samples from 100 paired HIV-1 infected ART naïve and experienced individuals and 100 prospectively collected matched blood-donor controls. Antinuclear antibody, IgG anticardiolipin antibody, IgM and IgG β2 glycoprotein-1 antibodies, and total IgG levels were detected. Results are expressed as mean with standard deviation (SD), median, percentage positivity, and a p<0.05 is considered significant. The study was approved by the Institutional Review Board.中文翻译：
HIV-1 感染者的自身抗体和抗逆转录病毒疗法 (ART) 对其的影响
背景：抗逆转录病毒疗法 (ART) 已导致自身免疫性疾病的减少，但缺乏对其对自身抗体影响的研究。
方法：这是一项横断面研究，存档样本来自 100 对 HIV-1 感染者的 ART 初治和经验丰富的个体，以及 100 名前瞻性收集的匹配献血者对照。检测抗核抗体、IgG 抗心磷脂抗体、IgM 和 IgG β2 糖蛋白-1 抗体以及总 IgG 水平。结果表示为平均值与标准偏差 (SD)、中值、阳性百分比，并且 p<0.05 被认为是显着的。该研究得到了机构审查委员会的批准。
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