Antibiotic use in swine production contributes to the emergence and spread of resistant bacteria, which poses a threat on human health. Therefore, alternative approaches must be developed. The objective of this work was the characterization of the probiotic properties of a Ligilactobacillus salivarius strain isolated from sow’s milk and its application as an inoculated fermented feed to pregnant sows and piglets. The study was carried in a farm in which metaphylactic use of antimicrobials (including zinc oxide) was eliminated at the time of starting the probiotic intervention, which lasted for 2 years. Feces from 8-week-old piglets were collected before and after the treatment and microbiological and biochemical analyses were performed. The procedure led to an increase in the concentrations of clostridia and lactobacilli-related bacteria. Parallel, an increase in the concentration of butyrate, propionate and acetate was observed and a notable reduction in the presence of antibiotic resistant lactobacilli became apparent. This strategy resulted in the improvement of all productivity parameters tested (mortality rates at weaning and fattening, total fattening days, daily weight increase and number of live born piglets per sow. In conclusion, replacement of antimicrobials by a microbiota-friendly approach was feasible and provided Public Health and economic benefits.

中文翻译：

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在养猪场中通过口服唾液乳酸杆菌 MP100MP100 替代干预防性抗菌疗法：对动物健康、公共卫生和农场经济的益处

养猪业中抗生素的使用会导致耐药细菌的出现和传播，对人类健康构成威胁。因此，必须开发替代方法。这项工作的目的是表征从母乳中分离出的唾液乳杆菌菌株的益生菌特性，及其作为怀孕母猪和仔猪接种发酵饲料的应用。该研究是在一个农场进行的，该农场在开始益生菌干预时就不再使用抗菌药物（包括氧化锌），该干预持续了两年。在治疗前后收集8周龄仔猪的粪便，并进行微生物学和生化分析。该过程导致梭状芽胞杆菌和乳酸杆菌相关细菌的浓度增加。与此同时，观察到丁酸盐、丙酸盐和乙酸盐的浓度增加，并且抗生素抗性乳杆菌的存在显着减少。该策略提高了所有测试的生产力参数（断奶和育肥死亡率、总育肥天数、日增重和每头母猪活产仔猪数量）。总之，用微生物群友好型方法替代抗菌药物是可行的，并且提供了公共卫生和经济效益。