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Mycobacterium tuberculosis SIT42 infection in an abused dog in Southern Italy
Frontiers in Veterinary Science ( IF 2.6 ) Pub Date : 2021-05-06 , DOI: 10.3389/fvets.2021.653360
Lucia Vangone 1 , Lorena Cardillo 2 , Marita Georgia Riccardi 3 , Giorgia Borriello 3 , Anna Cerrone 4 , Paolo Coppa 4 , Roberto Scialla 4 , Emanuela Sannino 3 , Gianluca Miletti 1 , Giorgio Galiero 5 , Giovanna Fusco 2
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A case of Mycobacterium tuberculosis infection is described in a dead adult male dog in Southern Italy. The carcass was found by the Health Authority in a gypsy encampment. It was admitted to our forensic veterinary medicine unit, with a suspect of cruelty to the animal. Necropsy showed beating and traumatism signs and mistreating was confirmed. Gross lesions included multiple nodular hepatic lesions, haemorrhagic enteritis with enlarged mesenteric lymph nodes, body cavity effusions and an adrenal neoplasm. Bacteriological and molecular analyses were carried out on the liver lesions that enabled to identify M. tuberculosis SIT42 (LAM9). Drug-resistance patterns were evaluated by screening mutations on the rpoB and katG genes that showed susceptibility to both rifampin and isoniazid, respectively. Very few studies report canine tuberculosis and little is known about the disease in Italy. To the authors’ knowledge, this is the first report of Mycobacterium tuberculosis SIT42 infection in a dog in Italy.

中文翻译:

意大利南部一只受虐狗身上的结核分枝杆菌SIT42感染

在意大利南部一只死去的成年雄性狗中描述了一例结核分枝杆菌感染的病例。the体是卫生局在吉普赛人营地发现的。它被送入我们的法医兽医部门,对动物有残酷嫌疑。尸检显示有跳动和创伤迹象,并确认有虐待行为。肉眼可见的病变包括多发结节性肝病变,出血性肠炎,肠系膜淋巴结肿大,体腔积液和肾上腺肿瘤。对能够鉴定结核分枝杆菌SIT42(LAM9)的肝脏病变进行了细菌学和分子分析。通过筛选rpoB和katG基因的突变来评估药物的耐药性,这些突变分别显示出对利福平和异烟肼的敏感性。很少有研究报告犬结核病,而在意大利对该病知之甚少。据作者所知,这是意大利一只狗中结核分枝杆菌SIT42感染的首次报道。
更新日期:2021-05-06
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