The importance of Salvia L. species, being used as traditional medicine, in the scientific world is increasing day by day. The relationship between health and traditional-modern life, promotes the creation of new value added food products. Within this context, in this study, it was aimed to biologically and chemically investigate the essential oil and ethanol extracts of the Salvia multicaulis Vahl. Chemical and biological study results of naturally grown and cultivated (uninvestigated in the literature) samples of S. multicaulis were compared. The essential oil, aroma and terpenoid-steroid contents of the species were determined by gas chromatography-mass spectrometry (GC–MS) and phenolic content by liquid chromatography-mass spectrometry/mass spectrometry (LC–MS/MS). In addition, the bioactivities of the extracts were screened for antioxidant, cytotoxic, antialzheimer, antiurease, antityrosinase, antielastase and anticollagenase activities. It was found that the enzyme activities of the essential oil and the antioxidant activities of all ethanol extracts of the species were quite high. It was determined that especially essential oil and the ethanol extracts of the leaf parts exhibited high cytotoxic effect in cancer cell lines (PDF (Healthy primary dermal fibroblast cell line), HT-29 (colon cancer cell line), MCF-7 (breast cancer cell line), Caco-2 (colon cancer cell line) and Skov-3 (ovary cancer cell line)). According to the GC–MS results, in the natural specimen 1,8-cineole (33.05 %) and d-limonene (21.18 %), in the cultivated sample 1,8-cineole (42.35 %) and α-pinene (15.74 %) were detected to be as the major components of the essential oil and aroma, respectively. It was observed that both natural and cultivated samples were rich in β-Sitosterol. Moreover, the root extract of natural samples was found to be richer than the other extracts in terms of abieatane diterpene (ferruginol, cryptanol, sugiol, and inuroyleanone) compounds. According to the LC–MS/MS results, it is seen that both natural and cultivated samples are very rich in rosmarinic acid. Especially, the flower part of the natural sample (98.10 mg analyte/g extract) was found to contain more rosmarinic acid than the other parts. Due to the high total phenolic and rosmarinic acid content, cytotoxic, anti-aging, and antioxidant potential of the ethanol extract of the leaf parts of the species, it has the potential to be used as a food supplement, food preservative and in the pharmaceutical industry.

在科学界中，作为传统药物使用的丹参属植物物种的重要性正在日益提高。健康与传统现代生活之间的关系，促进了新增值食品的创造。在此背景下，本研究旨在通过生物学和化学方法研究丹参多酚Vahl的精油和乙醇提取物。化学和自然生长和栽培（没有进行过在文献中）的样品的生物研究结果S. -多进行比较。该物种的精油，香气和萜类固醇含量通过气相色谱-质谱（GC-MS）测定，酚含量通过液相色谱-质谱/质谱（LC-MS / MS）测定。另外，针对抗氧化剂，细胞毒性，抗阿兹海默症，抗脲酶，抗酪氨酸酶，抗弹性蛋白酶和抗胶原酶活性，对提取物的生物活性进行了筛选。发现该物种的精油的酶活性和所有乙醇提取物的抗氧化活性都很高。已确定特别是叶的精油和乙醇提取物在癌细胞系（PDF（健康的原代皮肤成纤维细胞系），HT-29（结肠癌细胞系），MCF-7（乳腺癌）中表现出高细胞毒性作用细胞系），Caco-2（结肠癌细胞系）和Skov-3（卵巢癌细胞系）。根据GC-MS结果，天然样品中的1,8-桉树脑（33.05％）和在培养样品中，d-柠檬烯（21.18％）被检测为精油和香气的主要成分，分别为1,8-桉树脑（42.35％）和α -pine烯（15.74％）。观察到天然和栽培样品均富含β-谷固醇。此外，发现天然样品的根提取物比阿比他汀二萜（铁三酚，隐孢子醇，sugiol和inuroyleanone）化合物的富集程度比其他提取物要丰富。根据LC-MS / MS结果，可以看出，天然样品和培养样品中的迷迭香酸都非常丰富。尤其是，发现自然样品的花朵部分（98.10 mg分析物/ g提取物）比其他部分含有更多的迷迭香酸。由于该物种叶部分乙醇提取物的总酚和迷迭香酸含量高，具有细胞毒性，抗衰老和抗氧化的潜力，因此有潜力用作食品补充剂，食品防腐剂和药物行业。