Fusion products with the ETS family of transcription factors play critical roles in the etiology of several cancers. In this issue of Structure, Hou et al. (2020) provide insight into allosteric mechanisms by which mithramycin and its analogs perturb protein-DNA interactions in higher-order complexes at a DNA enhancer site.

中文翻译：

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深入了解光神霉素对ETS转录的破坏，可以增进对更多选择性类似物的了解

具有ETS转录因子家族的融合产物在几种癌症的病因中起着至关重要的作用。在本期《结构》中，侯等人。（2020年）提供了变构机制的洞察力，通过该变构，光神霉素及其类似物扰乱了DNA增强子位点更高阶复合物中的蛋白质-DNA相互作用。