Steroid receptors (SRs) are members of the nuclear hormonal receptor family, many of which are transcription factors regulated by ligand binding. SRs regulate various human physiological functions essential for maintenance of vital biological pathways, including development, reproduction and metabolic homeostasis. In addition, aberrant expression of SRs or dysregulation of their signaling has been observed in a wide variety of pathologies. SR activity is tightly and finely controlled by posttranslational modifications targeting the receptors and/or their coregulators. Whereas major attention has been focused on phosphorylation, growing evidence shows that methylation is also an important regulator of SRs. Interestingly, the protein methyltransferases depositing methyl marks are involved in many functions, from development to adult life. They have also been associated with pathologies such as inflammation, as well as cardiovascular and neuronal disorders, and cancer.

中文翻译：

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蛋白质甲基化如何调节类固醇受体功能

类固醇受体 (SR) 是核激素受体家族的成员，其中许多是受配体结合调节的转录因子。SRs 调节对维持重要生物途径至关重要的各种人体生理功能，包括发育、繁殖和代谢稳态。此外，已在多种病理中观察到 SR 的异常表达或其信号传导失调。SR 活性受到靶向受体和/或其辅助调节因子的翻译后修饰的严格和精细控制。尽管主要注意力集中在磷酸化上，但越来越多的证据表明甲基化也是 SR 的重要调节因子。有趣的是，沉积甲基标记的蛋白质甲基转移酶涉及许多功能，从发育到成年。