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Selective Consecutive Determination of Desloratadine and Montelukast Sodium in Their Pure and Binary Dosage Form Based on Pencil Graphite Electrochemical Sensors
Journal of Analytical Methods in Chemistry ( IF 2.3 ) Pub Date : 2021-05-05 , DOI: 10.1155/2021/5540907
Amir Alhaj Sakur 1 , Dania Nashed 1 , Imad Noureldin 1
Affiliation  

In this study, we present a new, green electrochemical method for potentiometric estimation of desloratadine and montelukast sodium in their pure and binary dosage form. For that, three pencil graphite sensors were fabricated; the first one was prepared to analyse desloratadine drug (DES) by coating the graphite bar with the coating membrane, which comprises the ion pair of desloratadine and ammonium reineckate reagent (RNK), the polymer poly vinyl chloride (PVC), and the plasticizers dibutyl phthalate (DBP). The second one, which was used to analyse montelukast (MON), was constructed by using the ion pair of cadmium chloride reagent (Cd.) with montelukast and the same earlier named polymer and plasticizer. As a trial to analyse both of the drugs by the same sensor consecutively, we have constructed a combined pencil graphite electrode, which contains the two earlier suggested ion pairs, that is, we can use this electrode to selectively analyse for each drug. The proposed electrodes were effectively used for analysis of DES and MON as a single dosage form and as combined pharmaceutical preparation, without any need for prior separation that was performed depending on the difference in the efficient pH range for each sensor. The proposed sensors exhibited a Nernstian equation slopes of −30.11, 27.70, (−29.16, 29.79) mv. decade−1 in the linearity range 5.00 × 10−5−1.00 × 10−2 and 1.00 × 10−5 − 1.00 × 10−2 M, respectively. The sensors exhibit high sensitivity according to LOD values ((0.036–0.018) − (0.025-0.026) µM), respectively, and important selectivity toward the studied drugs in presence of interfering ions and excipients. The optimum circumstances were studied, and the method was validated by application of ICH rules. Finally, the method was compared with a documented method, and the required statistical values were calculated.

中文翻译:

基于铅笔石墨电化学传感器的选择性连续测定地氯雷他定和孟鲁司特钠的纯净和二元剂量形式

在这项研究中,我们提出了一种新的绿色电化学方法,用于电位法评估地洛他定和孟鲁司特钠的纯和二元剂型。为此,制造了三个笔形石墨传感器。第一个制备方法是通过用涂膜覆盖石墨棒来分析去氯雷他定药物(DES),该膜包括去氯雷他定和Reineckate试剂(RNK)的离子对,聚合物聚氯乙烯(PVC)和增塑剂二丁基邻苯二甲酸盐(DBP)。第二个用于分析孟鲁司特(MON)的方法是,将氯化镉试剂(Cd。)的离子对与孟鲁司特以及较早的聚合物和增塑剂结合使用。为了通过同一传感器连续分析这两种药物,我们构建了一个组合式铅笔石墨电极,其中包含两个较早建议的离子对,也就是说,我们可以使用此电极对每种药物进行选择性分析。所提出的电极可有效地用于DES和MON的单剂型分析和药物组合制备,而无需根据每个传感器的有效pH范围的差异进行事先分离。拟议的传感器表现出30.11、27.70,(-29.16、29.79)mv的Nernstian方程斜率。十年 无需根据每个传感器的有效pH范围的差异进行事先分离。拟议的传感器表现出30.11、27.70,(-29.16、29.79)mv的Nernstian方程斜率。十年 无需根据每个传感器的有效pH范围的差异进行事先分离。拟议的传感器表现出30.11、27.70,(-29.16、29.79)mv的Nernstian方程斜率。十年-1中线性范围5.00×10 -5 -1.00×10 -2和1.00×10 -5  - 1.00×10 -2 分别男,。-所述传感器根据LOD值((0.025-0.026)(0.036-0.018)表现出高的灵敏度 μ分别,而重要的选择性朝向干扰离子和赋形剂的存在下研究药物M)。研究了最佳条件,并通过应用ICH规则对方法进行了验证。最后,将该方法与文献记载的方法进行比较,并计算出所需的统计值。
更新日期:2021-05-05
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