Purpose of Review

We aim to summarize the sleep disorders reported in patients affected by primary mitochondrial dysfunctions and describe the association with their clinical and molecular characteristics.

Recent Findings

Sleep complaints are prevalent in mitochondrial disorders. Sleep-disordered breathing is the main sleep disorder reported in mitochondrial diseases. OSA and CSA are, respectively, more frequently associated with patients characterized by the prevalent involvement of the skeletal muscle and the predominant involvement of the central nervous system. Other sleep disorders, such as restless legs syndrome, have been rarely described.

Summary

Sleep disorders are frequently associated with primary mitochondrial disorders, and the clinical phenotypes affect the type of sleep disturbance associated with the mitochondrial dysfunction. A polysomnographic study should be performed in every subject with this neurogenetic disorder both at diagnosis and during follow-up for the numerous adverse clinical outcomes associated with sleep disorders and the frailty of mitochondrial patients.

中文翻译：

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线粒体疾病中的睡眠障碍

审查目的

我们的目的是总结受原发性线粒体功能障碍影响的患者报告的睡眠障碍，并描述其与临床和分子特征的关联。

最近的发现

睡眠问题在线粒体疾病中很常见。睡眠呼吸障碍是线粒体疾病中报道的主要睡眠障碍。OSA 和 CSA 分别更常与骨骼肌普遍受累和中枢神经系统占主导地位的患者相关。其他睡眠障碍，例如不宁腿综合症，却很少被描述。

概括

睡眠障碍通常与原发性线粒体疾病相关，并且临床表型影响与线粒体功能障碍相关的睡眠障碍的类型。在诊断时和随访期间，应对每位患有这种神经遗传性疾病的受试者进行多导睡眠图研究，以了解与睡眠障碍和线粒体患者虚弱相关的众多不良临床结果。