Background: There is not much known about venom allergy in tropical regions. Here, we studied the prevalence of specific IgE (sIgE) and skin prick test (SPT) reactivity and reported sting-related symptoms, in high- and low-socioeconomic status (SES) schoolchildren living in urban city of Makassar in Indonesia. Methods: Children from high- (n = 160) and low- (n = 165) SES schools were recruited. Standardized questionnaires were used to record information on allergic disorders as well as sting-related symptoms. Parasitic infection, SPT reactivity, and sIgE to Apis mellifera (bee-venom) as well as Vespula spp. (wasp-venom) were assessed. Results: SPT reactivity to bee- and wasp-venom was 14.3 and 12.7%, while the prevalence of sIgE was 26.5 and 28.5%, respectively. When SES was considered, prevalence of SPT to bee- and wasp-venom was higher in high-SES than in low-SES schoolchildren (bee: 22.8 vs. 5.7%, p #x3c; 0.001; and wasp: 19.6 vs. 5.7%, p #x3c; 0.001). Conversely, sIgE to both venoms was lower in high-SES than in low-SES (bee: 19 vs. 34%, p = 0.016; and wasp: 19 vs. 38%, p = 0.003). Furthermore, among SPT positive subjects, considerable proportion had no detectable sIgE to bee- (65.85%) or wasp-venom (66.67%). Altogether the sensitizations were rarely translated into clinical reaction, as only 1 child reported significant local reaction after being stung. No association with parasitic infections was found. Conclusions and Clinical Relevance: Sensitization against bee- or wasp-venom is quite prevalent among schoolchildren in Indonesia. The discordance between SPT and sIgE might suggest the direct (non-IgE) effect of venoms in skin reactivity. Recorded sensitizations had poor clinical relevance as they rarely translated into clinical symptoms.
Int Arch Allergy Immunol

中文翻译：

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生活在印度尼西亚城市地区的高社会经济地位和低社会经济地位的学童对蜜蜂和黄蜂毒液的敏感性

背景：对热带地区的毒液过敏知之甚少。在这里，我们研究了居住在印度尼西亚望加锡市的高和低社会经济地位 (SES) 学童中特定 IgE (sIgE) 和皮肤点刺试验 (SPT) 反应性的流行情况，并报告了与蜇伤相关的症状。方法：招募了来自高 ( n = 160) 和低 ( n = 165) SES 学校的儿童。标准化问卷用于记录有关过敏性疾病以及刺痛相关症状的信息。寄生虫感染、SPT 反应性和对蜜蜂（蜂毒）和胡蜂属的sIgE。（黄蜂毒液）进行了评估。结果：SPT 对蜜蜂和黄蜂毒液的反应性分别为 14.3% 和 12.7%，而 sIgE 的流行率分别为 26.5% 和 28.5%。当考虑 SES 时，高 SES 中蜜蜂和黄蜂毒液的 SPT 流行率高于低 SES 学童（蜜蜂：22.8 对 5.7%，p #x3c；0.001；和黄蜂：19.6 对 5.7% , p #x3c; 0.001)。相反，高 SES 的两种毒液的 sIgE 低于低 SES（蜜蜂：19 对 34%，p = 0.016；黄蜂：19 对 38%，p= 0.003）。此外，在 SPT 阳性受试者中，相当多的人没有检测到蜜蜂（65.85%）或黄蜂毒液（66.67%）的 sIgE。总的来说，致敏反应很少转化为临床反应，因为只有 1 名儿童在被蜇伤后报告了明显的局部反应。未发现与寄生虫感染有关。结论和临床相关性：对蜜蜂或黄蜂毒液的过敏在印度尼西亚的学童中非常普遍。SPT 和 sIgE 之间的不一致可能表明毒液对皮肤反应性的直接（非 IgE）影响。记录的致敏性具有较差的临床相关性，因为它们很少转化为临床症状。
Int Arch 过敏免疫