Background and Aim: This study assesses whether individuals with substance use disorder are at greater risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than people in the general population. Methods: A population-based study was conducted including 3,780 individuals, diagnosed with alcohol or other drug dependence and cared for by the addiction service (AS) in the province of Reggio Emilia. Standardised incidence ratios (SIRs) and relative 95% confidence intervals (CIs) of being tested and of being SARS-CoV-2 positive in the population of interest compared with those in the general population of Reggio Emilia were calculated. Results: Both individuals with alcohol and those with other drug use disorders had a lower risk of being SARS-CoV-2 positive (SIR = 0.69; 95% CI 0.32–1.30, SIR = 0.56; 95% CI 0.24–1.10, respectively), despite higher rates of being tested than the general population (SIR = 1.48; 95% CI 1.14–1.89, SIR = 1.51; 95% CI 1.20–1.86, respectively). Among HIV-negative persons, 12.5% were positive to SARS-CoV-2, while none was positive among HIV-positive persons. HCV-infected AS clients had a higher risk of both being tested for SARS-CoV-2 (SIR = 1.99; 95% CI 1.26–2.98) and of resulting positive (SIR = 1.53; 95% CI 0.50–3.58). Conclusions: Individuals with alcohol and/or other drug use disorders are at higher risk of being tested for SARS-CoV-2 infection but at lower risk of resulting positive than the general population. Further research is warranted in order to support our findings and to address plausible factors underpinning such associations.
Eur Addict Res

中文翻译：

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物质使用障碍者感染 SARS-CoV-2 的风险更高吗？意大利北部基于人口的登记研究

背景和目的：本研究评估了物质使用障碍患者是否比一般人群更容易感染严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2)。方法：进行了一项基于人群的研究，包括 3,780 名被诊断患有酒精或其他药物依赖并由雷焦艾米利亚省戒毒服务中心 (AS) 照顾的人。计算了与雷焦艾米利亚普通人群相比，受测人群和 SARS-CoV-2 阳性的标准化发病率 (SIR) 和相对 95% 置信区间 (CI)。结果：尽管酗酒者和其他吸毒者的 SARS-CoV-2 阳性风险较低（SIR = 0.69；95% CI 0.32–1.30，SIR = 0.56；95% CI 0.24–1.10）检测率高于一般人群（分别为 SIR = 1.48；95% CI 1.14–1.89，SIR = 1.51；95% CI 1.20–1.86）。在 HIV 阴性者中，12.5% 的人对 SARS-CoV-2 呈阳性，而在 HIV 阳性者中没有人呈阳性。感染 HCV 的 AS 客户接受 SARS-CoV-2 检测（SIR = 1.99；95% CI 1.26–2.98）和结果呈阳性（SIR = 1.53；95% CI 0.50–3.58）的风险更高。结论：与一般人群相比，患有酒精和/或其他药物使用障碍的人接受 SARS-CoV-2 感染检测的风险更高，但结果呈阳性的风险更低。需要进一步研究以支持我们的发现并解决支持此类关联的合理因素。
欧洲瘾君子研究