Resveratrol is a naturally occurring polyphenolic compound exhibiting therapeutic activities. However, the stability can be altered by UV light, pH and changes in temperature. Encapsulation would be an ideal strategy to improve the stability and bioavailability. Thus, trans-resveratrol (Res) was encapsulated within hybrid nanoparticles consisted with silica and G4 polyamidoamine dendrimer (PAMAM) by sol-gel method. The diameters of synthesized nanoparticles (NPs) were at a range of 212–574 nm and the encapsulation efficiency was 86 %. RAW 264.7 murine macrophage cell line induced with endotoxin/lipopolysaccharide was treated with free resveratrol and Res-loaded NPs for assessing inhibition of inducible nitric oxide synthase (iNOS), where IC₅₀ values of free resveratrol and Res-loaded NPs were 122.68 µM and 249.74 µM. As for cytotoxicity, IC₅₀ values of free resveratrol were found as 176.57 µM and 201.54 µM for MCF-7 and MDA-MB-231 cells, whereas 197.16 µM and 219.07 µM for Res-loaded NPs for the respective cell lines. Overall, sol-gel technique proved to be an ideal technology as can be carried out under mild conditions and Res-loaded NPs have potential to be utilized in the industry.

白藜芦醇是一种天然的多酚化合物，具有治疗活性。但是，紫外线，pH值和温度变化会改变稳定性。包封将是提高稳定性和生物利用度的理想策略。因此，通过溶胶-凝胶法将反式白藜芦醇（Res）包封在由二氧化硅和G4聚酰胺酰胺胺树枝状大分子（PAMAM）组成的杂化纳米颗粒中。合成的纳米粒子（NPs）的直径范围为212–574 nm，封装效率为86％。将内毒素/脂多糖诱导的RAW 264.7鼠巨噬细胞系用游离白藜芦醇和Res负载的NPs处理以评估对诱导型一氧化氮合酶（iNOS）的抑制作用，其中IC ₅₀自由白藜芦醇和RES加载的NP的值分别为122.68 μ M和249.74 μ M.至于细胞毒性，IC _50个自由白藜芦醇的值被发现为176.57 μ M和201.54 μ M表示MCF-7和MDA-MB-231细胞，而197.16 μ M和219.07 μ M代表RES加载的NP针对各个细胞系。总体而言，溶胶-凝胶技术被证明是理想的技术，因为它可以在温和的条件下进行，并且重载NP具有在工业中使用的潜力。