In article number 2001750, Kui Zhu, Ben Zhong Tang and co‐workers demonstrate that aggregationinduced emission luminogens such as TBPs trigger ROS‐mediated membrane damage to effectively kill internalized bacteria without resistance development. Intriguingly, TBPs promote mitochondria dependent autophagy to eliminate such bacteria in host cells. Similar to vancomycin, TBPs demonstrate high efficacy against notorious bacterial infections in vivo.

中文翻译：

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针对多药耐药细菌：AIEgens体内有效杀死多药耐药内在细菌（Adv。Sci。9/2021）

朱奎，本中堂及其同事在第2001750号文章中证明，聚集诱导的发射性发光物质（如TBP）会触发ROS介导的膜损伤，从而有效杀死内在细菌而不会产生抗药性。有趣的是，TBP促进线粒体依赖性自噬，以消除宿主细胞中的此类细菌。与万古霉素相似，TBPs在体内对臭名昭著的细菌感染显示出很高的功效。