In article number 2003535, Rongrong Zhu and co‐workers report the role of MgFe‐LDH nanoparticles as a promising LIF replacement in maintaining mESCs self‐renewal and pluripotency. Combined transcriptomic and proteomic analysis reveals that MgFe‐LDH could activate LIFR regulating signaling pathways, while the extra Fe²⁺ provided by MgFe‐LDH also enhances TET1/2 abundance related to DNA demethylation. This biocompatible MgFe‐LDH nanoparticle favors economical and efficient replacement for LIF in large‐scale expansion of ESCs.

中文翻译：

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胚胎干细胞多能性：MgFe-LDH纳米颗粒：有望在培养的小鼠胚胎干细胞中实现自我更新和多能性维持的白血病抑制因子替代品（Adv。Sci。9/2021）

在文章2003535中，朱荣荣及其同事报告了MgFe-LDH纳米粒子在维持mESCs自我更新和多能性方面作为有希望的LIF替代品的作用。结合转录组和蛋白质组学分析表明，MgFe-LDH可以激活LIFR调控信号通路，而MgFe-LDH提供的额外Fe ²⁺也可以增强与DNA脱甲基有关的TET1 / 2丰度。这种具有生物相容性的MgFe-LDH纳米粒子有利于经济，有效地替代ESC大规模扩展中的LIF。