In article number 2001302, Silke Patz, Daniel T. Simon, Rainer Schindl, and co‐workers engineer an electronically‐driven ion pump for the targeted delivery of the charged chemotherapeutic gemcitabine to brain cancer cells. By delivering drug ions over a cation exchange membrane at currents in the nanoampere range, brain cancer cell death and microtumor disintegration is triggered. This local gemcitabine treatment offers a therapeutical window, in contrast to standard treatment.

中文翻译：

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有针对性的化学疗法：使用离子泵对成胶质细胞瘤球体进行有针对性的化学疗法（Adv。Mater。Technol。5/2021）

Silke Patz，Daniel T.Simon，Rainer Schindl及其同事在编号为2001302的产品中设计了一种电子驱动的离子泵，用于将带电的化疗药物吉西他滨靶向递送至脑癌细胞。通过以纳安级的电流在阳离子交换膜上输送药物离子，触发脑癌细胞死亡和微瘤崩解。与标准治疗相比，这种吉西他滨局部治疗提供了治疗窗口。