Pharmaceutical Chemistry Journal ( IF 0.8 ) Pub Date : 2021-05-05 , DOI: 10.1007/s11094-021-02386-0 S. K. Choi , N. N. Thi , J. E. Kwon , Y. G. Lee , S. C. Kang , N. I. Baek
Repeated column chromatography of solvent fractions extracted from the flowers of Lilium Asiatic hybrids ensured purification of three benzyl glycosides I – III, which were reliably identified based on the analysis of various spectroscopic data. Compounds I – III (20 μg/mL) reduced nuclear factor-kappa B (NF-kB) (p-p65/p-65) by 9.64 ± 0.66%, 30.98 ± 1.08%, and 54.04 ± 1.12%, respectively. Compounds II and III markedly inhibited the expression of vascular cell adhesion molecule 1 (VCAM-1) in tumor necrosis factor (TNF)-α-stimulated human aortic smooth muscle cells (HASMCs) by 38.68 ± 2.52% and 37.9 ± 2.76%, respectively. Compound III significantly suppressed U937 monocytes attachment to the TNF-α-stimulated HASMCs.
中文翻译:
亚洲百合百合花中的苄基糖苷的抗炎活性
对从亚洲百合属植物的花中提取的溶剂馏分进行反复柱色谱分析,可确保纯化三种I - III苄基糖苷,这些糖苷是根据各种光谱数据分析可靠地鉴定出来的。化合物I – III(20μg/ mL)分别将核因子-κB(NF-kB)(p-p65 / p-65)降低了9.64±0.66%,30.98±1.08%和54.04±1.12%。化合物II和III分别显着抑制肿瘤坏死因子(TNF)-α刺激的人主动脉平滑肌细胞(HASMCs)中血管细胞粘附分子1(VCAM-1)的表达,分别抑制38.68±2.52%和37.9±2.76% 。化合物III 显着抑制了U937单核细胞附着在TNF-α刺激的HASMC上。