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Anti-Inflammatory Activity of Benzyl Glycosides from the Flowers of Lilium Asiatic Hybrids
Pharmaceutical Chemistry Journal ( IF 0.8 ) Pub Date : 2021-05-05 , DOI: 10.1007/s11094-021-02386-0
S. K. Choi , N. N. Thi , J. E. Kwon , Y. G. Lee , S. C. Kang , N. I. Baek

Repeated column chromatography of solvent fractions extracted from the flowers of Lilium Asiatic hybrids ensured purification of three benzyl glycosides IIII, which were reliably identified based on the analysis of various spectroscopic data. Compounds IIII (20 μg/mL) reduced nuclear factor-kappa B (NF-kB) (p-p65/p-65) by 9.64 ± 0.66%, 30.98 ± 1.08%, and 54.04 ± 1.12%, respectively. Compounds II and III markedly inhibited the expression of vascular cell adhesion molecule 1 (VCAM-1) in tumor necrosis factor (TNF)-α-stimulated human aortic smooth muscle cells (HASMCs) by 38.68 ± 2.52% and 37.9 ± 2.76%, respectively. Compound III significantly suppressed U937 monocytes attachment to the TNF-α-stimulated HASMCs.



中文翻译:

亚洲百合百合花中的苄基糖苷的抗炎活性

对从亚洲百合属植物的花中提取的溶剂馏分进行反复柱色谱分析,可确保纯化三种I - III苄基糖苷,这些糖苷是根据各种光谱数据分析可靠地鉴定出来的。化合物IIII(20μg/ mL)分别将核因子-κB(NF-kB)(p-p65 / p-65)降低了9.64±0.66%,30.98±1.08%和54.04±1.12%。化合物IIIII分别显着抑制肿瘤坏死因子(TNF)-α刺激的人主动脉平滑肌细胞(HASMCs)中血管细胞粘附分子1(VCAM-1)的表达,分别抑制38.68±2.52%和37.9±2.76% 。化合物III 显着抑制了U937单核细胞附着在TNF-α刺激的HASMC上。

更新日期:2021-05-05
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