Research has primarily focused on additive (unique) associations between early stressful life experiences (specifically, socioeconomic adversity and maltreatment) and young adults’ cardiometabolic disease risk without considering multiplicative (synergistic) influences. Furthermore, research has not fully considered the varying patterns of health risk trajectories (e.g., substance use, obesogenic-related behaviors, depressive symptoms) across adolescence and the transition to young adulthood that may link earlier stressful experiences and later cardiometabolic disease risk. This study examined heterogeneity in conjoint health risk trajectories from adolescence to the transition to young adulthood and their additive and multiplicative (synergistic) influences with early stressful life experiences on cardiometabolic disease risk in young adulthood using data from the National Longitudinal Study of Adolescent to Adult Health (n = 9,421; 55.6% female) over a period of 13 years. Four distinct conjoint health risk trajectories were identified considering trajectories of substance use behaviors, obesogenic-related behaviors, and depressive symptoms: (a) overall high-risk, (b) behavioral risks, (c) psycho-obesogenic risks, and (d) overall low-risk. Socioeconomic adversity and maltreatment were additively and multiplicatively associated with cardiometabolic disease risk in young adulthood. Individuals with overall high-risk conjoint trajectories averaged higher cardiometabolic disease risk in young adulthood when they were exposed to early socioeconomic adversity. Implications for personalized interventions for individuals who have experienced multiple forms of health risks are discussed.

研究主要集中在早期压力性生活经历（特别是社会经济逆境和虐待）与年轻人的心脏代谢疾病风险之间的累加（唯一）关联，而未考虑乘法（协同）影响。此外，研究还没有完全考虑到青春期和过渡到年轻成年的健康风险轨迹的各种模式（例如，物质使用，与肥胖有关的行为，抑郁症状），这可能与较早的压力经历和较晚的心脏代谢疾病风险相关。n  = 9,421；55.6％的女性）在13年的时间里。考虑到物质使用行为，致肥胖相关行为和抑郁症状的轨迹，确定了四种不同的联合健康风险轨迹：（a）总体高风险，（b）行为风险，（c）心理致肥胖风险和（d）总体低风险。社会经济逆境和虐待与成年后心脏代谢疾病的风险加成和成倍相关。总体上具有高风险的联合轨迹的个体，在经历早期的社会经济逆境时，平均在年轻成年期患心脏代谢疾病的风险较高。讨论了个性化干预对经历多种形式健康风险的个人的影响。