We use a theoretical approach to examine the effect of a radial fluid flow or electric current on the growth and homeostasis of a cell spheroid. Such conditions may be generated by a drain of micrometric diameter. To perform this analysis, we describe the tissue as a continuum. We include active mechanical, electric, and hydraulic components in the tissue material properties. We consider a spherical geometry and study the effect of the drain on the dynamics of the cell aggregate. We show that a steady fluid flow or electric current imposed by the drain could be able to significantly change the spheroid long-time state. In particular, our work suggests that a growing spheroid can systematically be driven to a shrinking state if an appropriate external field is applied. Order-of-magnitude estimates suggest that such fields are of the order of the indigenous ones. Similarities and differences with the case of tumors and embryo development are briefly discussed.

我们使用理论方法来检查径向流体流动或电流对细胞球体的生长和稳态的影响。这种情况可能是由微米直径的排水管产生的。为了进行这种分析，我们将组织描述为连续体。我们在组织材料属性中包含主动机械、电气和液压组件。我们考虑球形几何形状并研究排水对细胞聚集体动力学的影响。我们表明，稳定的流体流动或排水管施加的电流能够显着改变球体的长期状态。特别是，我们的工作表明，如果施加适当的外场，生长的球体可以系统地被驱动到收缩状态。数量级估计表明，这些领域与本土领域具有同等水平。简要讨论了肿瘤和胚胎发育情况的异同。