Abstract

Dental cavities are the most prevalent, preventable disease worldwide providing a need for robust treatment options to restore both the form and function of decaying teeth. Here is a presentation of a possible regenerative pulp capping agent that can serve to restore tooth function while regenerating healthy dentin tissue over a long period of time. To achieve this goal a material needs to crosslink quickly, be structurally rigid, and support the proliferation and differentiation of stem cells contained within the dental pulp. In this study, calcium phosphate nanoparticles were embedded in polymer hydrogels of carboxymethyl-chitosan and a diglycidyl ether. The particle size, surface, and mechanical properties of these materials were characterized. These composites have moduli up to 3 MPa, support the culture of dental pulp stem cells more than 3 weeks and exhibit osteogenic potential even without osteogenic media. These composites demonstrate a promising potential as the next generation of pulp capping materials.

摘要

蛀牙是世界范围内最普遍、最可预防的疾病，因此需要强有力的治疗方案来恢复蛀牙的形式和功能。这是一种可能的再生牙髓盖帽剂的介绍，它可以在很长一段时间内恢复牙齿功能，同时再生健康的牙本质组织。为了实现这一目标，材料需要快速交联、结构刚性，并支持牙髓内干细胞的增殖和分化。在这项研究中，磷酸钙纳米颗粒嵌入羧甲基壳聚糖和二缩水甘油醚的聚合物水凝胶中。表征了这些材料的粒度、表面和机械性能。这些复合材料的模量高达 3 MPa，支持牙髓干细胞的培养超过 3 周，即使没有成骨培养基也能表现出成骨潜力。这些复合材料显示出作为下一代盖髓材料的潜力。