Therapeutic effects of CXCR4+ subpopulation of transgene-free induced cardiosphere-derived cells on experimental myocardial infarction,Cell Proliferation

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Therapeutic effects of CXCR4+ subpopulation of transgene-free induced cardiosphere-derived cells on experimental myocardial infarction
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-05-04 , DOI: 10.1111/cpr.13041
Jianyong Xu ₁ , Huimei Wu ₁ , Zhigang Mai ₁ , Junbo Yi ₁ , Xianqi Wang ₁ , Lingyun Li ₁ , Zhong Huang ₁

Affiliation

Myocardial infarction (MI) is the most predominant type of cardiovascular diseases with high mortality and morbidity. Stem cell therapy, especially cardiac progenitor cell therapy, has been proposed as a promising approach for cardiac regeneration and MI treatment. Previously, we have successfully generated cardiac progenitor-like cells, induced cardiosphere (iCS), via somatic reprogramming. However, the genome integration characteristic of virus-based reprogramming approach hampered their therapeutic applications due to the risk of tumour formation. In the current study, we aim to establish a safer iCS generation strategy with transgene-free approaches.

中文翻译：

无转基因诱导心脏球源细胞CXCR4+亚群对实验性心肌梗死的治疗作用

心肌梗死（MI）是心血管疾病中最主要的类型，具有高死亡率和发病率。干细胞疗法，尤其是心脏祖细胞疗法，已被提议作为心脏再生和 MI 治疗的一种有前途的方法。以前，我们已经通过体细胞重编程成功地生成了心脏祖细胞样细胞，即诱导心脏圈 (iCS)。然而，由于肿瘤形成的风险，基于病毒的重编程方法的基因组整合特征阻碍了它们的治疗应用。在当前的研究中，我们旨在通过无转基因方法建立更安全的 iCS 生成策略。

更新日期：2021-06-01

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