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Galectin-1 ameliorates perioperative neurocognitive disorders in aged mice
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2021-05-04 , DOI: 10.1111/cns.13645
Zhiwen Shen 1, 2 , Hui Xu 1, 2 , Wen Song 1, 2 , Chuwen Hu 1, 2 , Mingyan Guo 1, 2 , Jinfeng Li 3 , Junhua Li 1, 2, 4
Affiliation  

The incidence of perioperative neurocognitive disorders (PND) is higher in the elderly patients undergoing surgery. Microglia activation-mediated neuroinflammation is one of the hallmarks of PND. Galectin-1 has been identified as a pivotal modulator in the central nervous system (CNS), while the role of galectin-1 in PND induced by microglia-mediated neuroinflammation is still undetermined.

中文翻译:

Galectin-1 改善老年小鼠围手术期神经认知障碍

接受手术的老年患者围手术期神经认知障碍(PND)的发生率较高。小胶质细胞激活介导的神经炎症是 PND 的标志之一。Galectin-1 已被确定为中枢神经系统 (CNS) 中的关键调节剂,而 Galectin-1 在由小胶质细胞介导的神经炎症诱导的 PND 中的作用仍未确定。
更新日期:2021-06-11
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