Galectin-1 ameliorates perioperative neurocognitive disorders in aged mice,CNS Neuroscience & Therapeutics

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Galectin-1 ameliorates perioperative neurocognitive disorders in aged mice
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2021-05-04 , DOI: 10.1111/cns.13645
Zhiwen Shen _{1,

2} , Hui Xu _{1,

2} , Wen Song _{1,

2} , Chuwen Hu _{1,

2} , Mingyan Guo _{1,

2} , Jinfeng Li ₃ , Junhua Li _{1,

2,

4}

Affiliation

The incidence of perioperative neurocognitive disorders (PND) is higher in the elderly patients undergoing surgery. Microglia activation-mediated neuroinflammation is one of the hallmarks of PND. Galectin-1 has been identified as a pivotal modulator in the central nervous system (CNS), while the role of galectin-1 in PND induced by microglia-mediated neuroinflammation is still undetermined.

中文翻译：

Galectin-1 改善老年小鼠围手术期神经认知障碍

接受手术的老年患者围手术期神经认知障碍（PND）的发生率较高。小胶质细胞激活介导的神经炎症是 PND 的标志之一。Galectin-1 已被确定为中枢神经系统 (CNS) 中的关键调节剂，而 Galectin-1 在由小胶质细胞介导的神经炎症诱导的 PND 中的作用仍未确定。

更新日期：2021-06-11

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