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The role of NOTCH3 variants in Alzheimer's disease and subcortical vascular dementia in the Chinese population
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2021-05-04 , DOI: 10.1111/cns.13647
Lina Guo 1 , Bin Jiao 1, 2, 3 , Xinxin Liao 4 , Xuewen Xiao 1 , Weiwei Zhang 5 , Zhenhua Yuan 1 , Xixi Liu 1 , Lu Zhou 1 , Xin Wang 1 , Yuan Zhu 1 , Qijie Yang 1 , Junling Wang 1, 2, 3 , Beisha Tang 1, 2, 3 , Lu Shen 1, 2, 3, 6
Affiliation  

NOTCH3 gene mutations predominantly cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, a common etiology of subcortical vascular dementia (SVaD). Besides, there may be a pathogenic link between NOTCH3 variants and Alzheimer's disease (AD). We aimed to study the role of NOTCH3 variants in AD and SVaD patients.
更新日期:2021-07-09
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