The role of NOTCH3 variants in Alzheimer's disease and subcortical vascular dementia in the Chinese population,CNS Neuroscience & Therapeutics

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The role of NOTCH3 variants in Alzheimer's disease and subcortical vascular dementia in the Chinese population
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2021-05-04 , DOI: 10.1111/cns.13647
Lina Guo ₁ , Bin Jiao _{1,

2,

3} , Xinxin Liao ₄ , Xuewen Xiao ₁ , Weiwei Zhang ₅ , Zhenhua Yuan ₁ , Xixi Liu ₁ , Lu Zhou ₁ , Xin Wang ₁ , Yuan Zhu ₁ , Qijie Yang ₁ , Junling Wang _{1,

2,

3} , Beisha Tang _{1,

2,

3} , Lu Shen _{1,

2,

3,

6}

Affiliation

NOTCH3 gene mutations predominantly cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, a common etiology of subcortical vascular dementia (SVaD). Besides, there may be a pathogenic link between NOTCH3 variants and Alzheimer's disease (AD). We aimed to study the role of NOTCH3 variants in AD and SVaD patients.

更新日期：2021-07-09

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