Introduction: The skin prick test (SPT) is a reliable method to confirm sensitization in IgE-mediated allergic diseases; however, it has been reported to be affected by several personal and environmental factors. Our objective was to determine the factors affecting the skin reactivity to histamine and allergens and investigate whether it differs according to age in terms of reading time. Methods: A total of 500 patients, aged 4 months–18 years, were enrolled in the study. Wheal and flare reaction sizes were documented as the mean of the longest and the midpoint perpendicular diameter in the 5th, 10th, 15th, and 20th min. Skin reactivity was compared between children #x3e;24 and ≤24 months of age. Results: We found larger histamine and allergen wheal sizes in children #x3e;24 months than the ones ≤24 months of age (p #x3c; 0.001 and p = 0.007, respectively). The duration of maximum histamine reactivity was 15 min for children #x3e;24 months whereas 10 min for children ≤24 months of age. The number of children losing their histamine reactivity after 15 and 20 min was significantly higher in the smaller age-group. Multiple regression analysis revealed a larger histamine reactivity in children #x3e;24 months of age, having obesity, and having allergen sensitization (p = 0.002, p = 0.003, and p = 0.018, respectively). Conclusion: It seems more accurate to evaluate SPT after 10 min in children ≤24 months of age. Cutoff values and ideal measurement time according to individual factors such as age, body mass index, or atopy are needed.
Int Arch Allergy Immunol

中文翻译：

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在将皮肤点刺试验解释为年龄、体重指数和特应性影响反应时间和大小之前，请三思

简介：皮肤点刺试验 (SPT) 是确认 IgE 介导的过敏性疾病致敏的可靠方法；然而，据报告它受到若干个人和环境因素的影响。我们的目标是确定影响皮肤对组胺和过敏原反应性的因素，并研究它在阅读时间方面是否因年龄而异。方法：共有 500 名年龄在 4 个月至 18 岁之间的患者参加了该研究。风团和耀斑反应大小记录为第 5、10、15 和 20 分钟的最长和中点垂直直径的平均值。比较了#x3e；24 个月和≤24 个月大的儿童之间的皮肤反应性。结果：我们发现 #x3e；24 个月儿童的组胺和过敏原风团大小比 ≤ 24 个月大的儿童（分别为p #x3c；0.001 和p = 0.007）。儿童#x3e 的最大组胺反应持续时间为 15 分钟；24 个月，而 24 个月以下的儿童为 10 分钟。在较小年龄组中，在 15 和 20 分钟后失去组胺反应性的儿童数量明显更高。多元回归分析显示，#x3e；24 个月大、肥胖和过敏原致敏的儿童具有更大的组胺反应性（分别为p = 0.002、p = 0.003 和p = 0.018）。结论：对于 ≤ 24 个月大的儿童，在 10 分钟后评估 SPT 似乎更准确。根据年龄、体重指数或特应性等个体因素，需要截止值和理想的测量时间。
Int Arch 过敏免疫