Effects of electromagnetic fields on neuronal ion channels: a systematic review,Annals of the New York Academy of Sciences

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Effects of electromagnetic fields on neuronal ion channels: a systematic review
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2021-05-04 , DOI: 10.1111/nyas.14597
Federico Bertagna _{1,

2} , Rebecca Lewis _{1,

2} , S Ravi P Silva _{1,

3} , Johnjoe McFadden _{1,

4} , Kamalan Jeevaratnam _{1,

2}

Affiliation

Many aspects of chemistry and biology are mediated by electromagnetic field (EMF) interactions. The central nervous system (CNS) is particularly sensitive to EMF stimuli. Studies have explored the direct effect of different EMFs on the electrical properties of neurons in the last two decades, particularly focusing on the role of voltage-gated ion channels (VGCs). This work aims to systematically review published evidence in the last two decades detailing the effects of EMFs on neuronal ion channels as per the PRISM guidelines. Following a predetermined exclusion and inclusion criteria, 22 papers were included after searches on three online databases. Changes in calcium homeostasis, attributable to the voltage-gated calcium channels, were found to be the most commonly reported result of EMF exposure. EMF effects on the neuronal landscape appear to be diverse and greatly dependent on parameters, such as the field's frequency, exposure time, and intrinsic properties of the irradiated tissue, such as the expression of VGCs. Here, we systematically clarify how neuronal ion channels are particularly affected and differentially modulated by EMFs at multiple levels, such as gating dynamics, ion conductance, concentration in the membrane, and gene and protein expression. Ion channels represent a major transducer for EMF-related effects on the CNS.

中文翻译：

电磁场对神经元离子通道的影响：系统评价

化学和生物学的许多方面都是由电磁场 (EMF) 相互作用介导的。中枢神经系统 (CNS) 对 EMF 刺激特别敏感。在过去的二十年里，研究探索了不同 EMF 对神经元电特性的直接影响，特别关注电压门控离子通道 (VGC) 的作用。这项工作旨在系统地审查过去二十年中发表的证据，这些证据详细说明了电磁场对神经元离子通道的影响，符合 PRISM 指南。根据预先确定的排除和纳入标准，在三个在线数据库中搜索后纳入了 22 篇论文。发现电压门控钙通道引起的钙稳态变化是最常报告的 EMF 暴露结果。EMF 对神经元景观的影响似乎多种多样，并且在很大程度上取决于参数，例如场的频率、曝光时间和受照射组织的内在特性，例如 VGC 的表达。在这里，我们系统地阐明了神经元离子通道如何在多个层面上受到 EMF 的特别影响和差异调节，例如门控动力学、离子电导、膜中的浓度以及基因和蛋白质表达。离子通道是 EMF 相关效应对 CNS 的主要传感器。我们系统地阐明了神经元离子通道如何在多个层面上受到 EMF 的特别影响和差异调节，例如门控动力学、离子电导、膜中的浓度以及基因和蛋白质表达。离子通道是 EMF 相关效应对 CNS 的主要传感器。我们系统地阐明了神经元离子通道如何在多个层面上受到 EMF 的特别影响和差异调节，例如门控动力学、离子电导、膜中的浓度以及基因和蛋白质表达。离子通道是 EMF 相关效应对 CNS 的主要传感器。

更新日期：2021-05-04

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