Lasers are the pillars of modern photonics and sensing. Recent advances in microlasers have demonstrated its extraordinary lasing characteristics suitable for biosensing. However, most lasers utilized lasing spectrum as a detection signal, which can hardly detect or characterize nanoscale structural changes in microcavity. Here the concept of amplified structured light-molecule interactions is introduced to monitor tiny bio-structural changes in a microcavity. Biomimetic liquid crystal droplets with self-assembled lipid monolayers are sandwiched in a Fabry–Pérot cavity, where subtle protein-lipid membrane interactions trigger the topological transformation of output vector beams. By exploiting Amyloid β (Aβ)-lipid membrane interactions as a proof-of-concept, it is demonstrated that vector laser beams can be viewed as a topology of complex laser modes and polarization states. The concept of topological-encoded laser barcodes is therefore developed to reveal dynamic changes of laser modes and Aβ-lipid interactions with different Aβ assembly structures. The findings demonstrate that the topology of vector beams represents significant features of intracavity nano-structural dynamics resulted from structured light-molecule interactions.

中文翻译：

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用于监测微腔中淀粉样蛋白-脂质相互作用的拓扑编码矢量束

激光器是现代光子学和传感的支柱。微型激光器的最新进展已经证明了其非凡的激光特性，适用于生物传感。然而，大多数激光器利用激光光谱作为检测信号，很难检测或表征微腔中的纳米级结构变化。这里引入了放大结构光-分子相互作用的概念来监测微腔中微小的生物结构变化。具有自组装脂质单层的仿生液晶滴被夹在法布里-珀罗腔中，其中微妙的蛋白质-脂质膜相互作用触发输出矢量光束的拓扑变换。通过利用淀粉样蛋白β (A β )-脂质膜相互作用作为概念验证，证明矢量激光束可以被视为复杂激光模式和偏振态的拓扑。因此，拓扑编码激光条形码的概念被开发出来，以揭示激光模式的动态变化以及 A β脂质与不同 A β 组装结构的相互作用。研究结果表明，矢量光束的拓扑结构代表了由结构光-分子相互作用产生的腔内纳米结构动力学的显着特征。