Background. It has been suggested that the angiotensinogen (AGT) gene rs4762 (p.Thr174Met) polymorphism might be associated with myocardial infarction (MI) risk, but the study results are still debatable. Objective and Methods. In order to explore the relationship between AGT p.Thr174Met polymorphism and MI risk, the current meta-analysis involving 7657 subjects from 11 individual studies was conducted. Results. A significant association between AGT p.Thr174Met polymorphism and MI was found under recessive (OR: 2.26, 95% CI: 1.35-3.77, ), dominant (OR: 1.131, 95% CI: 1.016-1.260, ), codominant (OR: 2.198, 95% CI: 1.334-3.621, ), and additive (OR: 1.363, 95% CI: 1.132-1.641, ) genetic models. In the Asian subgroup, significantly increased MI risk was found under all genetic models (). No significant association between AGT p.Thr174Met polymorphism and MI was found under all genetic models in the Caucasian subgroup (). Conclusions. AGT p.Thr174Met variant might increase MI risk, especially within the Asian population. The Met174 allele of AGT p.Thr174Met might confer the risk for MI.

中文翻译：

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心肌梗塞和AGT p.Thr174Met多态性：对7657名受试者的荟萃分析

背景。有人建议，一个ngiotensinogen（AGT）基因rs4762（p.Thr174Met）多态性可能与心肌梗死（MI）风险有关，但研究结果仍然值得商榷。目的和方法。为了探讨AGT p.Thr174Met多态性与MI风险之间的关系，目前进行了荟萃分析，涉及11个独立研究的7657名受试者。结果。在隐性情况下，发现了AGT p.Thr174Met多态性与MI之间的显着相关性（OR：2.26，95％CI：1.35-3.77，），显性（OR：1.131、95％CI：1.016-1.260，），显性（OR：2.198、95％CI：1.334-3.621，）和添加剂（OR：1.363，95％CI：1.132-1.641，）遗传模型。在亚洲亚组中，在所有遗传模型下均发现MI风险显着增加（）。在白种人亚组的所有遗传模型下，未发现AGT p.Thr174Met多态性与MI之间存在显着关联（）。 结论。AGT p.Thr174Met变体可能会增加MI的风险，尤其是在亚洲人群中。AGT p.Thr174Met的Met174等位基因可能带来MI的风险。