Background. Osteoarthritis is becoming a global major cause of pain and functional disability worldwide, especially in the elderly population. Nowadays, evidence shows that mobilization with movement (MWM) has a beneficial effect on knee osteoarthritis subjects. However, its adequacy remains unclear. Objective. To review the best available evidence for the effectiveness of MWMs on pain reduction and functional improvement in patients with knee osteoarthritis. Methods. A comprehensive search of literature was conducted using the following electronic databases: Google Scholar, PubMed, Physiotherapy Evidence Database (PEDro), Science Direct, Cochrane Library, and Scopus. Only randomized controlled trials (RCTs) were included, and the methodological quality of the studies was appraised using the PEDro scale. It was reported according to the guideline of the PRISMA statement. Results. A total of 15 RCTs having 704 participants were included. The present systematic review suggests that there were significant differences between MWM groups and control groups in terms of visual analogue scale (VAS), Western Ontario and MacMaster Universities Osteoarthritis Index (WOMAC) scale, and flexion range of motion. Conclusions. This systematic review demonstrated that MWM was effective to improve pain, range of motion, and functional activities in subjects with knee osteoarthritis.

中文翻译：

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动员运动对膝骨关节炎治疗的有效性：随机对照试验的系统评价。

背景。骨关节炎正在成为全球范围内引起疼痛和功能障碍的全球主要原因，尤其是在老年人口中。如今，有证据表明，运动动员（MWM）对膝骨关节炎患者具有有益的作用。但是，它的适当性仍然不清楚。目标。审查关于MWMs在膝骨关节炎患者中减轻疼痛和改善功能的有效性的最佳可用证据。方法。使用以下电子数据库对文献进行了全面搜索：Google Scholar，PubMed，物理疗法证据数据库（PEDro），Science Direct，Cochrane图书馆和Scopus。仅包括随机对照试验（RCT），并使用PEDro量表评估研究的方法学质量。根据PRISMA声明的指南进行了报告。结果。总共包括15个RCT，共有704名参与者。目前的系统评价表明，在视觉模拟量表（VAS），西安大略省和麦克马斯特大学骨关节炎指数（WOMAC）量表以及活动屈曲范围方面，MWM组与对照组之间存在显着差异。结论。该系统评价表明，MWM可有效改善膝部骨关节炎患者的疼痛，活动范围和功能活动。