The HORMA domain protein REV7, also known as MAD2L2, interacts with a variety of proteins and thereby contributes to the establishment of different complexes. With doing so, REV7 impacts a diverse range of cellular processes and gained increasing interest as more of its activities became uncovered. REV7 has important roles in translesion synthesis and mitotic progression, and acts as a central component in the recently discovered shieldin complex that operates in DNA double-strand break repair. Here we discuss the roles of REV7 in its various complexes, focusing on its activity in genome integrity maintenance. Moreover, we will describe current insights on REV7 structural features that allow it to be such a versatile protein.

HORMA 结构域蛋白 REV7，也称为 MAD2L2，与多种蛋白质相互作用，从而有助于建立不同的复合物。通过这样做，REV7 影响了多种细胞过程，并且随着其更多活动被发现而引起越来越多的兴趣。REV7 在跨损伤合成和有丝分裂进程中具有重要作用，并且是最近发现的用于 DNA 双链断裂修复的 shieldin 复合物的核心成分。在这里，我们讨论 REV7 在其各种复合物中的作用，重点是其在基因组完整性维护中的活性。此外，我们将描述当前对 REV7 结构特征的了解，使其成为一种多功能蛋白质。