The Scrib module proteins, Scrib, Dlg, and Lgl, are conserved regulators of cell polarity in diverse biological contexts. Originally discovered as neoplastic tumor suppressors in the fruit fly Drosophila melanogaster, disruption of Scrib module components leads to tumorigenesis in mammalian epithelia and is associated with human cancers. With multiple protein interacting domains, Scrib module proteins function as determinants of basolateral identity in epithelial cells with apical-basal polarity while acting as signaling platform scaffold proteins. Recent studies have further revealed novel roles of the Scrib module in the control of epithelial architecture, ranging from polarity establishment and tricellular junction formation to planar spindle orientation during cell division. This review updates the current understanding of the molecular nature and physiological functions of the Scrib module with a focus on in vivo studies, providing a framework for how these protein dynamics affect the processes of epithelial organization.

Scrib 模块蛋白 Scrib、Dlg 和 Lgl 是不同生物环境中细胞极性的保守调节剂。最初在果蝇 Drosophila melanogaster 中作为肿瘤抑制因子被发现，Scrib 模块组件的破坏导致哺乳动物上皮肿瘤发生并与人类癌症有关。由于具有多个蛋白质相互作用域，Scrib 模块蛋白质在具有顶端-基底极性的上皮细胞中充当基底外侧身份的决定因素，同时充当信号平台支架蛋白。最近的研究进一步揭示了 Scrib 模块在控制上皮结构中的新作用，从极性建立和三细胞连接形成到细胞分裂过程中的平面纺锤体方向。这篇综述更新了当前对 Scrib 模块的分子性质和生理功能的理解，重点是体内 研究，为这些蛋白质动力学如何影响上皮组织的过程提供了一个框架。