ABSTRACT

introduction

Sertoli cells play central roles in the development of testis formation in fetuses and the initiation and maintenance of spermatogenesis in puberty and adulthood, and disorders of Sertoli cell proliferation and/or functional maturation can cause male reproductive disorders at various life stages. It’s well documented that various genes are either overexpressed or absent in Sertoli cells during the conversion of an immature, proliferating Sertoli cell to a mature, non-proliferating Sertoli cell, which are considered as Sertoli cell stage-specific markers. Thus, it is paramount to choose an appropriate Sertoli cell marker that will be used not only to identify the developmental, proliferative, and maturation of Sertoli cell status in the testis during the fetal period, prepuberty, puberty, or in the adult, but also to diagnose the mechanisms underlying spermatogenic dysfunction.

areas covered

In this review, we principally enumerated 5 categories of testicular Sertoli cell markers – including immature Sertoli cell markers, mature Sertoli cell markers, immature/mature Sertoli cell markers, Sertoli cell functional markers, and others.

expert opinion

By delineating the characteristics and applications of more than 20 Sertoli cell markers, this review provided novel Sertoli cell markers for the more accurate diagnosis and mechanistic evaluation of male reproductive disorders.

中文翻译：

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睾丸支持细胞的常见标志物

摘要

介绍

支持细胞在胎儿睾丸形成的发育以及青春期和成年期精子发生的启动和维持中起重要作用，支持细胞增殖和/或功能成熟的障碍可导致男性在不同生命阶段的生殖障碍。有充分的证据表明，在未成熟的增殖性支持细胞转化为成熟的非增殖性支持细胞的过程中，支持细胞中的各种基因要么过度表达，要么缺失，这被认为是支持细胞阶段特异性标志物。因此，选择合适的支持细胞标记物至关重要，它不仅可用于识别胎儿期、青春期前、青春期或成人睾丸中支持细胞状态的发育、增殖和成熟，

涵盖的领域

在这篇综述中，我们主要列举了 5 类睾丸支持细胞标志物——包括未成熟支持细胞标志物、成熟支持细胞标志物、未成熟/成熟支持细胞标志物、支持细胞功能标志物等。

专家意见

通过描述20多个支持细胞标志物的特点和应用，本综述为更准确地诊断和评估男性生殖障碍提供了新的支持细胞标志物。