The current article was designed to assess the role of chitosan nanoparticles (CNPs) in the management of hepatic injury induced by the hepatocarcinogen 2-nitropropane (2-NP). Rats were divided into three groups. The first group served as a control, the second group was injected with 2-NP, while the third group was treated with CNPs 1 h before 2-NP injection every other day for 4 weeks. The 2-NP injection upregulated serum AST and ALT activities, as well as hepatic TNF- α, IL-6, and MDA levels and the expression of vascular endothelial growth factor (VEGF) and caspase-3, whereas GSH contents and SOD activity were decreased. Immunohistochemistry investigations revealed that the hepatic protein expression of collagen I, inducible nitric oxide synthetase, proliferating cell nuclear antigen, cluster of differentiation, and p53 were upregulated. hematoxylin and eosin (H&E) and Masson’s trichrome stains supported the previous parameters, and CNPs ameliorated most of the previous biochemical parameters. CNPs achieved promising results in the limitation of 2-NP hepatotoxicity.

本文旨在评估壳聚糖纳米颗粒 (CNP) 在治疗肝癌物质 2-硝基丙烷 (2-NP) 引起的肝损伤中的作用。将大鼠分为三组。第一组作为对照，第二组注射2-NP，第三组在2-NP注射前1小时注射CNP，每隔一天注射一次，持续4周。2-NP注射液上调血清AST和ALT活性，以及​​肝脏TNF-α、IL-6和MDA水平以及血管内皮生长因子（VEGF）和caspase-3的表达，而GSH含量和SOD活性则上调。减少了。免疫组织化学研究显示，I 型胶原蛋白、诱导型一氧化氮合成酶、增殖细胞核抗原、分化簇和 p53 的肝蛋白表达上调。苏木精和伊红 (H&E) 和 Masson 三色染色支持之前的参数，CNP 改善了之前的大部分生化参数。CNPs 在限制 2-NP 肝毒性方面取得了有希望的结果。