Human papillomaviruses (HPVs) are oncogenic viruses causing most cervical cancers. Highly prevalent in young, sexually active women, only a minority of HPV infections persist. To better characterize the immuno-modulatory impact of early HPV infections, we measured changes in a panel of 20 cytokines in cervicovaginal samples collected from young women who were tested for HPV and self-reported for genital inflammation and infection symptoms. Multi-factor statistical analyses revealed that increased IL-1Alpha and IL-12/IL-23p40 concentrations were associated with HPV infection and that macrophage inflammatory proteins were associated in particular with high-risk HPV infections. ClinicalTrials.gov identifier NCT02946346

人乳头瘤病毒 (HPV) 是导致大多数宫颈癌的致癌病毒。在年轻、性活跃的女性中高度流行，只有少数 HPV 感染持续存在。为了更好地描述早期 HPV 感染的免疫调节影响，我们测量了从接受 HPV 检测并自我报告生殖器炎症和感染症状的年轻女性收集的宫颈阴道样本中一组 20 种细胞因子的变化。多因素统计分析显示，增加的 IL-1Alpha 和 IL-12/IL-23p40 浓度与 HPV 感染相关，巨噬细胞炎症蛋白尤其与高危 HPV 感染相关。ClinicalTrials.gov 标识符 NCT02946346