Abstract

The immune system response of transplant recipients is the main cause of allograft rejection; therefore, its suppression seems crucial. Nevertheless, immunosuppressive agents are largely ineffective against innate immune response. Innate immunity is immediately activated after transplantation and contribute to allograft inflammation and rejection. In this regard, understanding the mechanism of activation and targeting the components of innate immunity could improve allograft survival time. In this review, we discuss two scenarios in the innate immunity, i.e., danger and allogeneic signals in the context of both allogeneic and syngeneic graft. Moreover, the mechanisms of innate allorecognition (i.e., signal regulatory protein α-CD47 and paired immunoglobulin-like receptors-MHC I axis) are described, which can improve our clinical decisions to use a better therapeutic strategy.

摘要

移植受者的免疫系统反应是同种异体排斥反应的主要原因；因此，它的抑制似乎至关重要。然而，免疫抑制剂在很大程度上对先天免疫反应无效。先天免疫在移植后立即被激活，并导致同种异体移植炎症和排斥反应。在这方面，了解激活机制和靶向先天免疫的成分可以提高同种异体移植物的存活时间。在这篇综述中，我们讨论了先天免疫中的两种情况，即异基因和同基因移植物背景下的危险和异基因信号。此外，描述了先天同种异体识别（即信号调节蛋白α-CD47和成对的免疫球蛋白样受体-MHC I轴）的机制，