Background

Oxygen uptake efficiency slope (OUES) is a method for investigating cardiorespiratory fitness and is proposed as an alternative to overcome the limitations of traditional measures such as peak oxygen consumption (VO_2peak) for patients who do not achieve a maximum response, such as in Parkinson's disease (PD).

Objective

To assess the performance of individuals with PD during the six-minute walk test (6MWT) using the OUES.

Methods

This is an observational cross-sectional study including 12 individuals with PD and 12 healthy controls. Participants performed the 6MWT along with an analysis of exhaled gas kinetics. The OUES was determined from the last 16 s of the walk test. Multiple linear regression analyses were computed to explore associations between the independent (OUES) and the dependent variables (VO_2peak) controlled by group.

Results

The OUES was associated to VO_2peak on the 6MWT (β=0.24, p<0.01) in individuals with PD. The PD group had low performance on the 6MWT with a shorter distance walked (mean difference: -113.1 m; 95% CI: -203.2, -59.1) and worse cardiopulmonary condition with lower OUES values (mean difference: -0.52 [l/minO₂]/[l/minVE]; 95% CI: -0.83, -0.21) found in this same group.

Conclusions

Our results suggest that OUES is related to VO_2peak during the 6MWT, and therefore it could be used as a submaximal test evaluation tool which provides cardiopulmonary reserve data in individuals with PD.

中文翻译：

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摄氧效率斜率：一种次最大测试评估工具，可提供帕金森病患者的心肺储备数据

背景

摄氧效率斜率 (OUES) 是一种研究心肺健康的方法，并被提议作为一种替代方法来克服传统测量方法的局限性，例如无法达到最大反应的患者的峰值耗氧量 (VO _2peak )，例如在帕金森氏症中疾病（PD）。

客观的

使用 OUES 评估 PD 患者在六分钟步行测试 (6MWT) 中的表现。

方法

这是一项观察性横断面研究，包括 12 名 PD 患者和 12 名健康对照者。参与者进行了 6MWT 以及呼出气体动力学分析。OUES 是从步行测试的最后 16 秒确定的。计算多元线性回归分析以探索自变量 (OUES) 和由组控制的因变量 (VO _2peak )之间的关联。

结果

在 PD患者中，_OUES与 6MWT 的VO _2peak相关（β=0.24，p <0.01）。PD 组在 6MWT 上的表现较低，步行距离较短（平均差异：-113.1 m；95% CI：-203.2，-59.1）和更差的心肺状况，OUES 值较低（平均差异：-0.52 [l/minO ₂ ]/[ l / min VE]；95% CI：-0.83，-0.21) 在同一组中发现。

结论

我们的结果表明 OUES 与6MWT 期间的VO _2peak相关，因此它可以用作次最大测试评估工具，为 PD 患者提供心肺储备数据。