To evaluate the pharmacological property of glucoglycyrrhizin (GGL), a unique glycoside of glycyrrhetinic acid (GA), we investigated the anti-allergic effect of GGL on IgE-mediated immediate hypersensitivity in mice. GGL exhibited the antiallergic effect against IgE-mediated immediate hypersensitivity. At a dose of 100 mg/kg, GGL exhibited antiallergic activity equivalent to that of glycyrrhizin (GL). Furthermore, the pretreatment with anti-GA monoclonal antibody eliminated the antiallergic action of GGL. These results indicated that GGL may act in the same way as GL in the human body. Its safety should be verified for its use as a drug similar to GL.

为了评估甘草次酸 (GA) 的一种独特糖苷甘草甜素 (GGL) 的药理特性，我们研究了 GGL 对 IgE 介导的小鼠立即超敏反应的抗过敏作用。GGL 对 IgE 介导的速发型超敏反应具有抗过敏作用。在 100 mg/kg 的剂量下，GGL 表现出相当于甘草甜素 (GL) 的抗过敏活性。此外，用抗 GA 单克隆抗体预处理消除了 GGL 的抗过敏作用。这些结果表明 GGL 在人体内可能以与 GL 相同的方式起作用。应验证其作为类似于 GL 的药物使用的安全性。