The study aimed to evaluate the early feasibility of endovascular replacement of ascending aorta, aortic root (including aortic valve, AV), and mitral valve (MV) in one procedure with two self-expandable prostheses. Aortic valved-fenestrated-bifurcated (AVFB) and MV endografts of 10 healthy pigs (60–65kg) were customized and delivered through transapical and transseptal approach, respectively. Both endografts were successfully deployed in nine pigs (90%). Eight survived over 24 h, and the acute success rate was 80%. There was no significant increase in the mean trans-aortic, trans-mitral, and trans-LVOT pressure gradients after the operation. No coronary artery or LVOT obstruction and other electrocardiographic abnormality occurred. The transvalvular and paravalvular leak rates were low for both valves. Endovascular replacement of ascending aorta, AV, and MV in one procedure might be feasible.

Graphical Abstract

中文翻译：

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急性临床前研究中主动脉根部和二尖瓣联合经导管置换术

该研究旨在评估在一个手术中使用两个自膨胀假体进行升主动脉、主动脉根部（包括主动脉瓣，AV）和二尖瓣（MV）血管内置换的早期可行性。10 头健康猪 (60-65kg) 的主动脉瓣开窗分叉 (AVFB) 和 MV 内移植物分别通过经心尖和经间隔方法进行定制和交付。两种内移植物均成功用于九头猪（90%）。8例存活超过24小时，急性成功率为80%。术后平均经主动脉、经二尖瓣和经 LVOT 压力梯度没有显着增加。未发生冠状动脉或LVOT梗阻等心电图异常。两个瓣膜的跨瓣和瓣周漏率均较低。升主动脉血管内置换术，

图形概要