We conducted a prospective, observational study at the Adult CF Center, Ospedale Policlinico, Milano, Italy, from March 2017 to September 2019 to assess the prevalence and serotypes of Streptococcus pneumoniae (SP) in adults with CF naive to pneumococcal vaccination. Spontaneous sputum samples from 129 patients were analyzed for SP DNA and serotyped. SP was found in 24 subjects (19%) and the most common serotypes were 19F (16%), 4 (6%), and 9VA (3%). Higher FEV1 and non-pseudomonas infection significantly associate with SP on sputum. These results define a subgroup of patients that might deserve implementation of microbiological techniques directed to pneumococcal detection.

我们于 2017 年 3 月至 2019 年 9 月在意大利米兰 Ospedale Policlinico 的成人 CF 中心进行了一项前瞻性观察性研究，以评估肺炎链球菌(SP) 在未接种肺炎球菌疫苗的 CF 成人中的流行率和血清型。对来自 129 名患者的自发痰样本进行 SP DNA 分析并进行血清分型。在 24 名受试者 (19%) 中发现了 SP，最常见的血清型为 19F (16%)、4 (6%) 和 9VA (3%)。较高的 FEV1 和非假单胞菌感染与痰中的 SP 显着相关。这些结果定义了可能值得实施针对肺炎球菌检测的微生物技术的患者亚组。