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The decidual expression of Interleukin-7 is upregulated in early pregnancy loss
American Journal of Reproductive Immunology ( IF 3.6 ) Pub Date : 2021-05-02 , DOI: 10.1111/aji.13437
Theresa Vilsmaier 1 , Niklas Amann 1 , Sanja Löb 1, 2 , Elisa Schmoeckel 3 , Christina Kuhn 4 , Alaleh Zati Zehni 1 , Sarah Meister 1 , Susanne Beyer 1 , Theresa M Kolben 1 , Johanna Becker 1 , Jan-Niclas Mumm 5 , Sven Mahner 1 , Udo Jeschke 1, 4 , Thomas Kolben 1
Affiliation  

Maternal immunological rejection of the semi-allogenic fetus is discussed as one of the significant factors involved in early pregnancy loss. An array of cytokines secreted by both maternal and fetal cells is involved in generating a delicate maternal immune tolerance. Interleukin-7 (IL-7) is discussed to play a key role in pro-inflammatory processes, but there is still limited insight into the pathophysiological input on placentation and embryonic development in early pregnancy loss.

中文翻译:

白细胞介素7的蜕膜表达在早期妊娠丢失中上调

半同种异体胎儿的母体免疫排斥被认为是早期妊娠丢失的重要因素之一。母体和胎儿细胞分泌的一系列细胞因子参与产生微妙的母体免疫耐受。讨论了白细胞介素 7 (IL-7) 在促炎过程中发挥关键作用,但对早期妊娠丢失中胎盘和胚胎发育的病理生理学输入的了解仍然有限。
更新日期:2021-05-02
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