Problem: Circadian rhythms are involved not only in the repair and regeneration of the immune system, but may also be associated with regulation of inflammation and immune responses. Rev-erbα could constitute a link between immunity and circadian rhythms since it is a transcription factor that regulates circadian rhythms and has functions in multiple physiological and pathological processes. Decidual macrophages (dMφs) play crucial roles in immune balance at the maternal-fetal interface, and abnormal macrophage polarization is related to adverse pregnancy outcomes, such as infertility, recurrent spontaneous abortion, and preterm labor. However, whether Rev-erbα could modulate the polarization of macrophages is unknown.

中文翻译：

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昼夜节律相关的 Rev-erbα 通过 PI3K/Akt 信号通路调节蜕膜巨噬细胞的极化

问题：昼夜节律不仅涉及免疫系统的修复和再生，还可能与炎症和免疫反应的调节有关。Rev-erbα 可能构成免疫和昼夜节律之间的联系，因为它是一种调节昼夜节律的转录因子，并在多种生理和病理过程中发挥作用。蜕膜巨噬细胞（dMφs）在母胎界面的免疫平衡中起关键作用，异常巨噬细胞极化与不良妊娠结局有关，如不孕、复发性自然流产和早产。然而，Rev-erbα是否可以调节巨噬细胞的极化尚不清楚。