The synthesis and characterization of four platinum(II) complexes using azobenzenes conveniently functionalized as ligands has been carried out. The characteristic photochemical behavior of the complexes due to the presence of azobenzene-type ligands and the role of the ligands in the activation of the complexes has been studied. Their promising cytotoxicity observed in HeLa cells prompted us to study the mechanism of action of these complexes as cytostatic agents. The interaction of the compounds with DNA, studied by circular dichroism, revealed a differential activity of the Pt(II) complexes upon irradiation. The intercalation abilities of the complexes as well as their reactivity with common proteins present in the blood stream allows to confirm some of the compounds obtained as good anticancer candidates.

已经进行了使用方便地功能化的偶氮苯作为配体的四种铂 (II) 配合物的合成和表征。由于偶氮苯型配体的存在以及配体在配合物活化中的作用，研究了配合物的特征光化学行为。它们在 HeLa 细胞中观察到的有希望的细胞毒性促使我们研究这些复合物作为细胞抑制剂的作用机制。通过圆二色性研究化合物与 DNA 的相互作用揭示了 Pt(II) 复合物在辐照时的不同活性。复合物的嵌入能力以及它们与血流中常见蛋白质的反应性允许确认获得的一些化合物是良好的抗癌候选物。