Anxiety-related behaviors are among the most prevalent psychiatric disorders in patients with type 2 diabetes (T2D). The protective effect of exercise on neuropsychiatric disorders has been documented. However, there are no studies that examined whether swimming exercise can decrease anxiety-like symptoms in type 2 diabetes. We investigated the effects of swimming exercise on body weight, anxiety-like behavior, glucose and insulin levels, and brain oxidative stress in male C57BL/6 mice. T2D-induced mice were subjected to swimming exercise, then anxiety-like behaviors were measured by the open field, light-dark box, and elevated plus-maze tests. Glucose and insulin levels were measure in serum, and antioxidant/oxidative markers including glutathione (GSH), malondialdehyde (MDA), and glutathione disulfide (GSSG) were measured in the brain. Our findings showed that T2D increased body weight, anxiety-like symptoms, glucose and insulin resistance, and oxidative stress by increasing MDA and GSSG levels in the brain of mice. Interestingly, swimming exercise reversed these parameters in diabetic mice. Our findings clearly indicate that there is a protective impact of swimming exercise on anxiety-like behavior by reducing insulin resistance and brain oxidative stress in mice with type 2 diabetes. Further studies are needed to validate these findings in humans.

焦虑相关行为是2型糖尿病（T2D）患者中最普遍的精神疾病。运动对神经精神疾病的保护作用已有文献记载。但是，没有研究检查游泳运动是否可以减轻2型糖尿病的焦虑样症状。我们调查了游泳运动对雄性C57BL / 6小鼠体重，焦虑样行为，葡萄糖和胰岛素水平以及脑氧化应激的影响。T2D诱导的小鼠进行游泳运动，然后通过开放视野，明暗框和高架迷宫测试测量类似焦虑的行为。测量血清中的葡萄糖和胰岛素水平，并测量大脑中的抗氧化剂/氧化性标志物，包括谷胱甘肽（GSH），丙二醛（MDA）和谷胱甘肽二硫化物（GSSG）。我们的研究结果表明，T2D通过增加小鼠大脑中MDA和GSSG的水平来增加体重，焦虑样症状，葡萄糖和胰岛素抵抗以及氧化应激。有趣的是，游泳运动可以逆转糖尿病小鼠的这些参数。我们的发现清楚地表明，游泳运动可以通过降低2型糖尿病小鼠的胰岛素抵抗和脑部氧化应激而对焦虑样行为产生保护作用。需要进一步的研究来验证人类的这些发现。我们的发现清楚地表明，游泳运动可以通过降低2型糖尿病小鼠的胰岛素抵抗和脑部氧化应激而对焦虑样行为产生保护作用。需要进一步的研究来验证人类的这些发现。我们的发现清楚地表明，游泳运动可以通过降低2型糖尿病小鼠的胰岛素抵抗和脑部氧化应激而对焦虑样行为产生保护作用。需要进一步的研究来验证人类的这些发现。